{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:42:14Z","timestamp":1790415734133,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Fistula laser closure (FiLaC\u2122) is a novel sphincter\u2010saving procedure for the treatment of anal fistula. Primary closure of the track is achieved using laser energy emitted by a radial fibre connected to a diode laser. The energy causes shrinkage of the tissue around the radial fibre with the aim being to close the track. This pilot study was designed to investigate the safety and effectiveness of this new technique in the treatment of anal fistula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Thirty\u2010five patients with anal fistula underwent the FiLaC\u2122 procedure. They had either a primary or a recurrent trans\u2010sphincteric anal fistula, a previously placed seton or a fistula involving a significant portion of the sphincter with a potential risk of postoperative incontinence on fistulotomy. The surgical procedure consisted of \u2018sealing\u2019 the fistula by laser energy. The primary end\u2010point was cure of the disease and evaluation of morbidity. The secondary end\u2010point was an assessment of the degree of postoperative continence using the Cleveland Clinic Florida (<jats:styled-content style=\"fixed-case\">CCF<\/jats:styled-content>) Fecal Incontinence Score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median operation time was 20\u00a0(6\u201335)\u00a0min. No intra\u2010operative complications were reported. Median duration of follow up was 20\u00a0(3\u201336)\u00a0months. Primary healing was observed in 25 (71.4%) patients. There were eight (23%) failures and two recurrences at 3 and 6\u00a0months after the operation. No patient reported incontinence postoperatively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The laser FiLaC\u2122 procedure for fistula\u2010in\u2010ano is a safe, relatively simple, minimally invasive, sphincter\u2010saving procedure with a high chance of success.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12440","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:24:11Z","timestamp":1381544651000},"page":"110-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":137,"title":["Closure of fistula\u2010in\u2010ano with laser \u2013 FiLaC\u2122: an effective novel sphincter\u2010saving procedure for complex disease"],"prefix":"10.1111","volume":"16","author":[{"given":"P.","family":"Giamundo","sequence":"first","affiliation":[{"name":"Department of General Surgery Hospital Santo Spirito Bra CN Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Geraci","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Santo Spirito Bra CN Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tibaldi","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Santo Spirito Bra CN Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Valente","sequence":"additional","affiliation":[{"name":"Department of General Surgery Hospital Santo Spirito Bra CN Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-011-0726-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02050307"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.04.030"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejvs.2010.04.006"},{"key":"e_1_2_9_6_1","first-page":"581","article-title":"Total anal sphincter saving technique for fistula\u2010in\u2010ano: the ligation of intersphincteric fistula tract","volume":"90","author":"Rojanasakul A","year":"2007","journal-title":"J Med Assoc Thai"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2011.02723.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i28.3286"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e318203495d"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03050.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9191-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181a80e24"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03025.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0055-3"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12440","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12440","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T10:45:04Z","timestamp":1743936304000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,22]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/codi.12440"],"URL":"https:\/\/doi.org\/10.1111\/codi.12440","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,22]]},"assertion":[{"value":"2013-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-07-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}