{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:09:29Z","timestamp":1777489769818,"version":"3.51.4"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Limited literature exists on whether slow colonic transit adversely influences the results of outlet obstruction surgery. We compared the functional results of laparoscopic ventral rectopexy (<jats:styled-content style=\"fixed-case\">LVR<\/jats:styled-content>) for obstructed defaecation secondary to high grade internal rectal prolapse in patients with normal and slow colonic transit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Consecutive patients suffering from obstructed defaecation associated with an internal rectal prolapse, who underwent an <jats:styled-content style=\"fixed-case\">LVR<\/jats:styled-content> between 2007 and 2011, were identified from a prospective database. All patients underwent preoperative defaecating proctography, anorectal manometry and colonic transit studies. Symptoms were assessed preoperatively and at 12\u00a0months after operation using a standardized questionnaire incorporating the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>atient <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>onstipation <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ymptoms (<jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SYM<\/jats:styled-content>) questionnaire, the <jats:styled-content style=\"fixed-case\">F<\/jats:styled-content>ecal <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ncontinence <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>everity <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex (<jats:styled-content style=\"fixed-case\">FISI<\/jats:styled-content>), the <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>atient <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>ssessment of <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>onstipation <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uality of <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ife (<jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>) scale and the <jats:styled-content style=\"fixed-case\">G<\/jats:styled-content>astrointestinal <jats:styled-content style=\"fixed-case\">Q<\/jats:styled-content>uality of <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>ife <jats:styled-content style=\"fixed-case\">I<\/jats:styled-content>ndex (<jats:styled-content style=\"fixed-case\">GIQLI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 151 patients underwent <jats:styled-content style=\"fixed-case\">LVR<\/jats:styled-content>, 109 with normal and 42 with slow colonic transit. Preoperatively there was no significant difference between the two groups in age, sex, <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SYM<\/jats:styled-content> score or <jats:styled-content style=\"fixed-case\">FISI<\/jats:styled-content> score. The <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SYM<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FISI<\/jats:styled-content> scores were significantly reduced in both groups at 12\u00a0months (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). When comparing the change from baseline of <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">SYM<\/jats:styled-content> between patients with and without slow transit constipation, a significant difference was observed (<jats:italic><jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.030) with changes of 58% and 40%. Quality of life (<jats:styled-content style=\"fixed-case\">GIQLI<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PAC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">QOL<\/jats:styled-content>) was equally improved in both groups. Quality of life improvement was less in patients with right colonic stasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Slow colonic transit has no adverse impact on function and quality of life after <jats:styled-content style=\"fixed-case\">LVR<\/jats:styled-content> for obstructed defaecation due to high grade internal rectal prolapse.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12443","type":"journal-article","created":{"date-parts":[[2013,10,14]],"date-time":"2013-10-14T07:59:05Z","timestamp":1381737545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Impact of slow transit constipation on the outcome of laparoscopic ventral rectopexy for obstructed defaecation associated with high grade internal rectal prolapse"],"prefix":"10.1111","volume":"15","author":[{"given":"M. P.","family":"Gosselink","sequence":"first","affiliation":[{"name":"Oxford Pelvic Floor Centre Department of Colorectal Surgery Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Adusumilli","sequence":"additional","affiliation":[{"name":"Oxford Pelvic Floor Centre Department of Colorectal Surgery Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Harmston","sequence":"additional","affiliation":[{"name":"Oxford Pelvic Floor Centre Department of Colorectal Surgery Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. A.","family":"Wijffels","sequence":"additional","affiliation":[{"name":"Oxford Pelvic Floor Centre Department of Colorectal Surgery Churchill Hospital Oxford UK"},{"name":"Department of Colorectal Surgery Zuwe Hofpoort Hospital Woerden Woerden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O. M.","family":"Jones","sequence":"additional","affiliation":[{"name":"Oxford Pelvic Floor Centre Department of Colorectal Surgery Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Oxford Pelvic Floor Centre Department of Colorectal Surgery Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Lindsey","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Zuwe Hofpoort Hospital Woerden Woerden The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,11,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2007.04051.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199911000-00004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(01)00820-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234290"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237050"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.29.7.969"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0834-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.02049.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01259.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-003-0572-2"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9378-1"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750025327"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236199"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510012208"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800820229"},{"key":"e_1_2_8_17_1","first-page":"141","article-title":"Simplified measurement of colonic transit time by one radiography of the abdomen and a single type of marker. 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