{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T01:22:49Z","timestamp":1779326569128,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2013,11,21]],"date-time":"2013-11-21T00:00:00Z","timestamp":1384992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The optimal strategy for intravenous (<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) fluid management during administration of hyperthermic intraperitoneal chemotherapy (<jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content>) is unclear. In this prospective study we describe the use of a <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>i<jats:styled-content style=\"fixed-case\">DCO<\/jats:styled-content><jats:italic>rapid<\/jats:italic>\u2122 (Li<jats:styled-content style=\"fixed-case\">DCO<\/jats:styled-content>, Cambridge, <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>) cardiac output monitor to guide <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> fluid management during cytoreductive surgery (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>) with <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content>. The aim of this study was to determine whether cardiac output monitoring will allow close maintenance of physiological parameters during the <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content> phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Twenty\u2010five patients who underwent <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> combined with <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content> were included in the study. Intra\u2010operative <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> fluid boluses were titrated using parameters measured by the <jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>i<jats:styled-content style=\"fixed-case\">DCO<\/jats:styled-content><jats:italic>rapid<\/jats:italic>\u2122 monitor. Stroke volume variation was maintained below 10% with fluid boluses and mean arterial pressure was maintained within 20% of the baseline figure with vasopressors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant change in heart rate and cardiac output. The systemic vascular resistance dropped from an average of 966 dyn.s\/cm\u20105 to 797\u00a0dyn\u00a0s\/cm<jats:sup>5<\/jats:sup> at 60\u00a0min during the <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content> phase (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.62) despite an increase in the dose of phenylepherine. The average total volume of fluid given was 748\u00a0ml in the first 30\u00a0min and 630\u00a0ml in the second 30\u00a0min with an average urine output of 307 and 445\u00a0ml, respectively. The change in lactate levels was not statistically or clinically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">L<\/jats:styled-content>i<jats:styled-content style=\"fixed-case\">DCO<\/jats:styled-content><jats:italic>rapid<\/jats:italic>\u2122 is an effective noninvasive tool for guiding fluid management in this population. It allows the anaesthesiologist to maintain tight control of essential physiological parameters during a phase of the procedure in which there is a risk of renal injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12444","type":"journal-article","created":{"date-parts":[[2013,10,12]],"date-time":"2013-10-12T02:28:11Z","timestamp":1381544891000},"page":"1537-1542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The use of cardiac output monitoring to guide the administration of intravenous fluid during hyperthermic intraperitoneal chemotherapy"],"prefix":"10.1111","volume":"15","author":[{"given":"K.","family":"Thanigaimani","sequence":"first","affiliation":[{"name":"Department of Anaesthetics Basingstoke and North Hampshire Hospital Basingstoke UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Surgery Basingstoke and North Hampshire Hospital Basingstoke UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Cecil","sequence":"additional","affiliation":[{"name":"Department of Surgery Basingstoke and North Hampshire Hospital Basingstoke UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. 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