{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:17:43Z","timestamp":1782922663308,"version":"3.54.5"},"reference-count":11,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,22]],"date-time":"2014-01-22T00:00:00Z","timestamp":1390348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Urgent colectomy for severe <jats:italic>Clostridium difficile<\/jats:italic> infection can be associated with increased morbidity and mortality. We aimed to use endoscopic methods for treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We describe a technique of placing an intracolonic tube facilitating decompression and direct delivery of vancomycin to the proximal colon along with enemas on a regular and frequent basis that may not be possible with vancomycin enemas alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Successful resolution of the <jats:italic>C. difficile<\/jats:italic> infection and avoidance of surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While further long\u2010term evaluation is required, our initial results have shown it to be effective in treating select patients with recalcitrant <jats:italic>Clostridium difficile<\/jats:italic>\u2010associated megacolon.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12463","type":"journal-article","created":{"date-parts":[[2013,10,17]],"date-time":"2013-10-17T15:41:21Z","timestamp":1382024481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Colonic decompression and direct intraluminal medical therapy for <i><scp>C<\/scp>lostridium difficile<\/i>\u2010associated megacolon using a tube placed endoscopically in the proximal colon"],"prefix":"10.1111","volume":"16","author":[{"given":"M. W.","family":"Causey","sequence":"first","affiliation":[{"name":"Department of Surgery Madigan Army Medical Center Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Surgery Madigan Army Medical Center Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Cummings","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Madigan Army Medical Center Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. K.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Surgery Madigan Army Medical Center Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Maykel","sequence":"additional","affiliation":[{"name":"University of Massachusetts Medical Center Worcester Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Steele","sequence":"additional","affiliation":[{"name":"Department of Surgery Madigan Army Medical Center Tacoma Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,1,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.09.017"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31822ade48"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2010.026"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02237064"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.2007.46"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.1909"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234641"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.450"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/TA.0b013e318265d19f"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/651706"},{"key":"e_1_2_6_12_1","first-page":"104","article-title":"Colon dynamics in ileus","volume":"49","author":"Schmidt E","year":"1978","journal-title":"Chirurg"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12463","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T10:45:23Z","timestamp":1743936323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,22]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.1111\/codi.12463"],"URL":"https:\/\/doi.org\/10.1111\/codi.12463","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,22]]},"assertion":[{"value":"2013-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-08-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}