{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T15:09:09Z","timestamp":1769612949723,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2014,4]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>Following treatment with argon plasma coagulation (APC<\/jats:styled-content>), rectal ulceration is seen in approximately 50% of patients with haemorrhagic chronic radiation proctitis (CRP<\/jats:styled-content>).<\/jats:p>This study aimed to assess the frequency of rectal ulcers (defined as a mucosal defect of 3\u00a0mm or more in diameter) in relation to the use of antiplatelet treatment for concomitant cardiovascular disease.<\/jats:p><\/jats:sec>Method<\/jats:title>Sixty\u2010two patients with CRP<\/jats:styled-content> were included in this retrospective study. Patients underwent pelvic irradiation due to prostate cancer (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>28), cervical cancer (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>16), endometrial cancer (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>17) or rectal cancer (n\u00a0<\/jats:italic>=\u00a0<\/jats:italic>1). APC<\/jats:styled-content> was performed in all patients. Control endoscopies were performed at 8 and 16\u00a0weeks after enrolment.<\/jats:p><\/jats:sec>Results<\/jats:title>Rectal ulcers were observed after APC<\/jats:styled-content> in 35 (56%) patients. They were symptomatic in 5 and asymptomatic in 30. The 20 (32%) patients who were on antiplatelet therapy had a significantly lower risk of ulceration after APC<\/jats:styled-content> (OR<\/jats:styled-content>\u00a0=\u00a00.21; 95% CI<\/jats:styled-content> 0.049\u20130.91; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.019). The number of symptomatic ulcers (5% vs<\/jats:italic> 10%; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>1.0) and asymptomatic ulcers alone (30% vs<\/jats:italic> 58%; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0.06) was also lower in patients respectively taking and not taking antiplatelet therapy, but these differences did not reach statistical significance.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Argon plasma coagulation\u2010related ulceration in patients treated for CRP<\/jats:styled-content> is less common when concomitant antiplatelet treatment is administered. This preliminary finding suggests that antiplatelet therapy may benefit patients treated with APC<\/jats:styled-content> for CRP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12465","type":"journal-article","created":{"date-parts":[[2013,10,19]],"date-time":"2013-10-19T11:58:40Z","timestamp":1382183920000},"page":"293-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The protective role of antiplatelet treatment against ulcer formation due to argon plasma coagulation in patients treated for chronic radiation proctitis"],"prefix":"10.1111","volume":"16","author":[{"given":"M. R.","family":"Chruscielewska\u2010Kiliszek","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medical Center for Postgraduate Education Warsaw Poland"},{"name":"Department of Gastroenterology Maria Sklodowska\u2010Curie Memorial Cancer Center and Institute of Oncology Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rupinski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medical Center for Postgraduate Education Warsaw Poland"},{"name":"Department of Gastroenterology Maria Sklodowska\u2010Curie Memorial Cancer Center and Institute of Oncology Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kraszewska","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medical Center for Postgraduate Education Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pachlewski","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medical Center for Postgraduate Education Warsaw Poland"},{"name":"Department of Gastroenterology Maria Sklodowska\u2010Curie Memorial Cancer Center and Institute of Oncology Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Regula","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Medical Center for Postgraduate Education Warsaw Poland"},{"name":"Department of Gastroenterology Maria Sklodowska\u2010Curie Memorial Cancer Center and Institute of Oncology Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clon.2007.07.008"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e3182587aef"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24223"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2004.03448.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214726"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2003.144"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(97)00063-7"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radphyschem.2004.04.140"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300563"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(03)01395-6"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-966284"},{"key":"e_1_2_8_13_1","first-page":"40","article-title":"The natural history of radiation induced proctosigmoiditis: an analysis of 88 patients","volume":"205","author":"Gilinsky RH","year":"1983","journal-title":"Q J Med"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12465","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:30:27Z","timestamp":1695479427000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,14]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,4]]}},"alternative-id":["10.1111\/codi.12465"],"URL":"https:\/\/doi.org\/10.1111\/codi.12465","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,14]]},"assertion":[{"value":"2012-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-06-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}