{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:45:35Z","timestamp":1790426735291,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T00:00:00Z","timestamp":1394755200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2014,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Rectal sucralfate has been reported to deliver clinical improvement in haemorrhagic radiation proctitis, but patients with active proctitis find the enema suspension difficult to retain thus reducing compliance and effectiveness. We describe a novel method of rectal administration via a low\u2010volume sucralfate paste and report its results in a series of 23 patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with rectal bleeding occurring more than 6\u00a0months after radiotherapy were shown how to prepare and self\u2010administer sucralfate paste enemas (<jats:styled-content style=\"fixed-case\">SPE<\/jats:styled-content>s) twice daily for 6\u00a0weeks. The <jats:styled-content style=\"fixed-case\">SPE<\/jats:styled-content> was prepared using two sucralfate 1\u2010g tablets mixed with 4.5\u00a0ml of water in an enema applicator producing a low\u2010volume paste. The clinical response was evaluated by comparison of pre\u2010 and posttreatment clinical proctitis scores (Radiation Therapy Oncology Group\/European Organisation for Research and Treatment of Cancer).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen male (postprostatic radiotherapy) and five female (postcervical radiotherapy) patients with a median age of 67 (32\u201375) years were included. The median interval between pelvic irradiation and <jats:styled-content style=\"fixed-case\">SPE<\/jats:styled-content> treatment was 24 (7\u201369) months. Twenty\u2010two patients had full clinical scoring, of whom 16 (73%) demonstrated clinical improvement. Six (27%) had neither clinical improvement nor deterioration. Seven (32%) had resolution of all symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Most patients demonstrated clinical improvement. This initial experience of the sucralfate paste enema may provide the basis for a prospective study of its effectiveness in the treatment of haemorrhagic radiation proctitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12507","type":"journal-article","created":{"date-parts":[[2013,12,2]],"date-time":"2013-12-02T14:02:55Z","timestamp":1385992975000},"page":"281-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Sucralfate paste enema: a new method of topical treatment for haemorrhagic radiation proctitis"],"prefix":"10.1111","volume":"16","author":[{"given":"K.","family":"McElvanna","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Royal Victoria Hospital Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Victoria Hospital Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Irwin","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Victoria Hospital Belfast UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2010.04.001"},{"key":"e_1_2_6_3_1","unstructured":"RTOG\/EORTC Late Radiation Morbidity Scoring Schema. 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