{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:20:16Z","timestamp":1780118416604,"version":"3.54.0"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,5,16]],"date-time":"2014-05-16T00:00:00Z","timestamp":1400198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2014,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Complications of colonic diverticula, perforation and bleeding are a source of morbidity and mortality. A variety of drugs have been implicated in these complications. We present a systemic review and meta\u2010analysis of the literature to assess the importance of this relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A systematic review of articles in PubMed, Cochrane Reviews, Embase and Google Scholar was undertaken in February 2013. An initial literature search yielded 2916 results that were assessed for study design and topicality. Twenty\u2010three articles were included in the review. A qualitative data synthesis was conducted using forest plots of studies comparing single medication with complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Individual studies demonstrated the odds of perforation and abscess formation with nonsteridal anti\u2010inflammatory drugs (<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s) (1.46\u201310.30), aspirin (0.66\u20132.40), steroids (2.17\u201331.90) and opioids (1.80\u20134.51) and the odds of bleeding with<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s (2.01\u201312.60), paracetamol (0\u20133.75), aspirin (1.14\u20133.70) and steroids (0.57\u20135.40). Pooled data showed significantly increased odds of perforation and abscess formation with<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s (OR\u00a0=\u00a02.49), steroids (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a09.08) and opioids (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.52). They also showed increased odds of diverticular bleeding from<jats:styled-content style=\"fixed-case\">NSAID<\/jats:styled-content>s (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.69), aspirin (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a03.24) and calcium\u2010channel blockers (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a02.50). Most studies did not describe the duration or dosage of medication used and did not systematically describe the severity of diverticular complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Various common medications are implicated in complications of diverticular disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12516","type":"journal-article","created":{"date-parts":[[2013,12,10]],"date-time":"2013-12-10T04:42:42Z","timestamp":1386650562000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Increased diverticular complications with nonsteriodal anti\u2010inflammatory drugs and other medications: a systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"16","author":[{"given":"C. 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