{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:21:40Z","timestamp":1770816100668,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The study aimed to determine the adequacy of the distal margin in patients having preoperative chemoradiotherapy (<jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>) followed by restorative surgery for rectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 368 patients with locally advanced rectal cancer treated for cure at our institution between <jats:styled-content style=\"fixed-case\">J<\/jats:styled-content>uly 1999 and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>arch 2009 were included in the study. All underwent preoperative <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> and sphincter\u2010sparing surgery. The distal margin and other factors were examined for their effect on recurrence and survival. The median duration of follow\u2010up was 48\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The length of distal margin ranged from 0 to 9.0\u00a0cm (median 1.5\u00a0cm). The pelvic control and disease\u2010free survival rates at 5\u00a0years for patients with a margin of \u2264\u00a03\u00a0mm were no different from those in whom it was &gt;\u00a03\u00a0mm (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.6 and 0.8). The 5\u2010year pelvic control rates between the \u2264\u00a03\u00a0mm and &gt;\u00a03\u00a0mm groups were 66.7 and 86.2% in patients with a yp<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>3\u20134 tumour (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.049) and 70.0 and 89.1% in patients who showed no response to <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.039).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest that a distal margin of &lt;\u00a03\u00a0mm in the surgical specimen after preoperative <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content> is associated with a lower rate of pelvic tumour control at 5\u00a0years in patients with <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>tage yp<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>3\u20134 tumours or in those who do not respond to <jats:styled-content style=\"fixed-case\">CRT<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12554","type":"journal-article","created":{"date-parts":[[2014,1,15]],"date-time":"2014-01-15T06:46:36Z","timestamp":1389768396000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The adequacy of the distal resection margin after preoperative chemoradiotherapy for rectal cancer"],"prefix":"10.1111","volume":"16","author":[{"given":"T. G.","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Samsung Changwon Hospital Sungkyunkwan University School of Medicine Changwon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. H.","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.\u2010H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. C.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. O.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. 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