{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:09:38Z","timestamp":1790791778670,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Total\/subtotal colectomy with ileorectal (<jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content>) or ileosigmoid (<jats:styled-content style=\"fixed-case\">ISA<\/jats:styled-content>) anastomosis is associated with various reported rates of morbidity, function and quality of life. Our object was to determine these end\u2010points in a series of patients undergoing these operations in our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>All patients who underwent <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">ISA<\/jats:styled-content> between 1994 and 2009 were retrospectively reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 320 patients (female 49%) with a median age of 54.2 (16.8\u201390.6) years underwent 338 <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">ISA<\/jats:styled-content> (in 18 patients the anastomosis was done twice) for inflammatory bowel disease (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>96), polyposis (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>95) and colorectal cancer (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>97). Mortality and morbidity rates were 1.2% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4) and 19.5% (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>66) and 47 surgical complications (13.9%) occurred, including 26 (7.7%) cases of anastomotic leakage, leading to 23 re\u2010operations. After a median follow\u2010up of 49 (0\u2013196) months, 262 patients still had a functioning anastomosis; 45 patients had died and 13 had a proctectomy. Information on function was obtained in 51.4% (133\/259) of the cohort after a median follow\u2010up of 77 (10\u2013196) months. The mean (\u00b1 standard deviation) rates of 24\u00a0h and nocturnal defaecation were 3.6\u00a0\u00b1\u00a02.4 and 0.5\u00a0\u00b1\u00a00.9. A disturbance of faecal or flatus continence occurred in 20% and 21% of patients. There was no case of faecal incontinence to solid stool. The mean <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036 <jats:styled-content style=\"fixed-case\">P<\/jats:styled-content>hysical and <jats:styled-content style=\"fixed-case\">M<\/jats:styled-content>ental <jats:styled-content style=\"fixed-case\">H<\/jats:styled-content>ealth <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ummary <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>cales were 46.3\u00a0\u00b1\u00a09.3 and 51.9\u00a0\u00b1\u00a09.3. Multivariate analysis showed that <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content> and inflammatory bowel disease were both independently associated with poorer long\u2010term function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Colectomy with <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">ISA<\/jats:styled-content> is safe with low postoperative morbidity and mortality. The employment of <jats:styled-content style=\"fixed-case\">IRA<\/jats:styled-content> and inflammatory bowel disease appear to be independent negative factors on function in multivariate analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12558","type":"journal-article","created":{"date-parts":[[2014,1,16]],"date-time":"2014-01-16T05:52:48Z","timestamp":1389851568000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Immediate outcome, long\u2010term function and quality of life after extended colectomy with ileorectal or ileosigmoid anastomosis"],"prefix":"10.1111","volume":"16","author":[{"given":"J.","family":"Duclos","sequence":"first","affiliation":[{"name":"Department of Digestive Surgery Saint\u2010Antoine Hospital University Pierre and Marie Curie, Paris VI Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Chafai","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery Saint\u2010Antoine Hospital University Pierre and Marie Curie, Paris VI Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Tiret","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery Saint\u2010Antoine Hospital University Pierre and Marie Curie, Paris VI Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Parc","sequence":"additional","affiliation":[{"name":"Department of Digestive Surgery Saint\u2010Antoine Hospital University Pierre and Marie Curie, Paris VI Paris 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