{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T14:51:54Z","timestamp":1775919114227,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2014,7,17]],"date-time":"2014-07-17T00:00:00Z","timestamp":1405555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Limited data are available on the relationship between the histological features of the resected specimens in patients with ulcerative colitis (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>) or indeterminate colitis (<jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>) and the outcome of restorative proctocolectomy. The aim of our study was to determine if the histological features of the resected specimen in patients with <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> can predict ileal\u2010pouch\u2010related outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A review of all patients who had a restorative proctocolectomy created following completion proctectomy or proctocolectomy for <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content> was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 1992 and 2011, 142 patients (132 with <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> and 10 with <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>) were reviewed. After a median follow\u2010up of 36 (3\u2013149) months, 51 (35.9%) developed a pouch\u2010related complication. Forty\u2010two (29.7%) developed pouchitis while three (2.1%) developed a pouch\u2010cutaneous fistula. Four (2.8%) had pouch failure, while stricture of the anastomosis was seen in three (2.1%) patients. The presence of extension of the inflammation into the muscularis propria of the resected specimen was associated with an increased risk of pouch\u2010related complications (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0.01). The presence of submucosal oedema was also a significant risk factor (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The extension of inflammation into the muscularis propria appears to predict pouch\u2010related complications following restorative proctocolectomy for <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12614","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T08:40:50Z","timestamp":1395132050000},"page":"620-625","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The extent of inflammation is a predictor for pouch\u2010related complications in ileal pouches in patients with ulcerative or indeterminate colitis"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0410-0450","authenticated-orcid":false,"given":"K.\u2010K.","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Royal Prince Alfred Hospital Sydney Australia"},{"name":"Surgical Outcomes Research Centre Central Sydney Area Health Service and University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ravindran","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Prince Alfred Hospital Sydney Australia"},{"name":"Surgical Outcomes Research Centre Central Sydney Area Health Service and University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Prince Alfred Hospital Sydney Australia"},{"name":"Surgical Outcomes Research Centre Central Sydney Area Health Service and University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Solomon","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Prince Alfred Hospital Sydney Australia"},{"name":"Surgical Outcomes Research Centre Central Sydney Area Health Service and University of Sydney Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,7,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31827d99a2"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236894"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.20278"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000080825.95166.26"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gassur.2005.08.013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e31819f5d4c"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010136"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9194-7"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2007.03.020"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236726"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-006-0247-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2007.01413.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199805000-00006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000126758.35603.8d"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.2006.02545.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.6.690"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200207000-00008"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199711000-00009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2005.00800.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.510"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.11.1539"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.5.671"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1097\/00054725-200008000-00001","article-title":"Pouchitis is associated with mucosal imbalance between interleukin\u20108 and interleukin\u201010","volume":"6","author":"Bulois P","year":"2000","journal-title":"Inflamm Bowel Dis"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28017"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.2.234"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050162"},{"key":"e_1_2_8_28_1","first-page":"622","article-title":"Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch\u2013anal anastomosis","volume":"211","author":"Lohmuller JL","year":"1990","journal-title":"Ann Surg"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12614","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:30:05Z","timestamp":1695493805000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,17]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/codi.12614"],"URL":"https:\/\/doi.org\/10.1111\/codi.12614","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,17]]},"assertion":[{"value":"2013-09-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-07-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}