{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T16:40:27Z","timestamp":1765039227538},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T00:00:00Z","timestamp":1410825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2014,10]]},"abstract":"Abstract<\/jats:title>Aim<\/jats:title>There is debate about whether the traditional three\u2010tiered grading of anal intraepithelial neoplasia (AIN<\/jats:styled-content>) should be replaced by a more reproducible two\u2010tiered system. In this study, we review our experience with AIN<\/jats:styled-content> to determine the most suitable classification system.<\/jats:p><\/jats:sec>Method<\/jats:title>We performed a retrospective review of all histological reports over a 19\u00a0year period. All specimens were graded on haemataloxin and eosin appearance and those with dysplasia had immunohistochemistry for p16 and Ki67 performed.<\/jats:p><\/jats:sec>Results<\/jats:title>Cases included 25 condyloma acuminata, 11 dysplastic cases and 24 invasive squamous cell carcinomas. On review, 18 were classified as condyloma acuminata without dysplasia. Seven had AIN<\/jats:styled-content> I, five had AIN II<\/jats:styled-content> and six had AIN III<\/jats:styled-content> when using a three\u2010tiered system. All cases classified as dysplastic (n\u00a0<\/jats:italic>=\u00a018) showed an increased proliferation index as measured by Ki67. p16 positivity was seen in all AIN III<\/jats:styled-content>, two AIN II<\/jats:styled-content> and none of the AIN<\/jats:styled-content> I cases. Recurrence was not observed in any of the AIN<\/jats:styled-content> I cases. Five of eleven AIN II<\/jats:styled-content> and AIN III<\/jats:styled-content> cases recurred or persisted at a similar, higher or lower grade. Both of the AIN II<\/jats:styled-content> cases which recurred or persisted were p16 positive. None of the AIN II<\/jats:styled-content> cases that were p16 negative recurred. Three of the p16\u2010positive AIN III<\/jats:styled-content> cases did not recur. None of the 18 AIN<\/jats:styled-content> cases progressed to carcinoma.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>The findings support the slow progression of AIN<\/jats:styled-content> as described in the literature. In our small series, a two\u2010tiered system with further subclassification of the traditional AIN II<\/jats:styled-content> group using p16 appears to be clinically useful.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12679","type":"journal-article","created":{"date-parts":[[2014,6,2]],"date-time":"2014-06-02T18:24:21Z","timestamp":1401733461000},"page":"777-782","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anal intraepithelial neoplasia: a single centre 19\u00a0year review"],"prefix":"10.1111","volume":"16","author":[{"given":"M. B.","family":"Cotter","sequence":"first","affiliation":[{"name":"Department of Histopathology Centre for Colorectal Disease St. Vincent's University Hospital & School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Surgery, Centre for Colorectal Disease St. Vincent's University Hospital & School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. R.","family":"O'Connell","sequence":"additional","affiliation":[{"name":"Department of Surgery, Centre for Colorectal Disease St. Vincent's University Hospital & School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Hyland","sequence":"additional","affiliation":[{"name":"Department of Surgery, Centre for Colorectal Disease St. Vincent's University Hospital & School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Winter","sequence":"additional","affiliation":[{"name":"Department of Surgery, Centre for Colorectal Disease St. Vincent's University Hospital & School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sheahan","sequence":"additional","affiliation":[{"name":"Department of Histopathology Centre for Colorectal Disease St. Vincent's University Hospital & School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Gibbons","sequence":"additional","affiliation":[{"name":"Department of Histopathology Centre for Colorectal Disease St. Vincent's University Hospital & School of Medicine and Medical Sciences University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003163421107"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2010.02498.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d6818"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.143"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4967"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/344057"},{"key":"e_1_2_8_8_1","first-page":"372","article-title":"Interobserver variability in the diagnosis of anal cancer precursor lesions: study of the usual scenario","volume":"38","author":"Costa E","year":"2011","journal-title":"Rev Col Bras Cir"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.47.11.1032"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.LGT200570"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2010.02494.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181f0f52a"},{"key":"e_1_2_8_14_1","first-page":"364","article-title":"Management of anal cancer in 2010. Overview, screening and diagnosis","volume":"24","author":"Abbas A","year":"2010","journal-title":"Oncology"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2013.04.011"},{"key":"e_1_2_8_16_1","first-page":"194","article-title":"On etiology of anal squamous carcinoma","volume":"49","author":"Frisch M","year":"2002","journal-title":"Dan Med Bull"},{"key":"e_1_2_8_17_1","first-page":"87","article-title":"Increasing incidence of squamous cell carcinoma of the anus in Scotland 1975\u20102002","volume":"95","author":"Brewster DH","year":"2006","journal-title":"Br J Surg"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-12-398"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-199511000-00007"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9233-4"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70080-3"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2006.03837.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92961-E"},{"issue":"2","key":"e_1_2_8_24_1","first-page":"159A","article-title":"The natural history of anal squamous dyspasia \u2013 an eight year follow up study","volume":"26","author":"Kavusi S","year":"2013","journal-title":"Mod Pathol"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6744-5"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20927"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.4137\/CPath.S501"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mpdhp.2013.11.005"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65689-1"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt235"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12679","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:00:40Z","timestamp":1696309240000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12679"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,16]]},"references-count":29,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/codi.12679"],"URL":"https:\/\/doi.org\/10.1111\/codi.12679","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,16]]},"assertion":[{"value":"2014-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}