{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T10:19:14Z","timestamp":1769077154740,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Helse Vest Research Foundation"},{"DOI":"10.13039\/501100007872","name":"Grieg Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007872","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Strain elastography is a novel approach to rectal tumour evaluation. The primary aim of this study was to correlate elastography to pT stages of rectal tumours and to assess the ability of the method to differentiate rectal adenomas (pT0) from early rectal cancer (pT1\u20132). Secondary aims were to compare elastography with endorectal ultrasonography (<jats:styled-content style=\"fixed-case\">ERUS<\/jats:styled-content>) and to propose a combined strain elastography and <jats:styled-content style=\"fixed-case\">ERUS<\/jats:styled-content> staging algorithm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In all, 120 consecutive patients with a suspected rectal tumour were examined in this staging study. Patients receiving surgery without neoadjuvant radiotherapy were included (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>59). All patients were examined with <jats:styled-content style=\"fixed-case\">ERUS<\/jats:styled-content> and elastography. Treatment decisions were made by multidisciplinary team (<jats:styled-content style=\"fixed-case\">MDT<\/jats:styled-content>) assessment, without considering the strain elastography examination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histopathology identified 21 adenomas, 13 pT1, 9 pT2, 15 pT3 and one pT4. Mean elastography strain ratios were predictive of T stage (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01). Differentiation of adenomas from early rectal cancer (pT1\u20132) had sensitivity, specificity and accuracy of 0.82, 0.86 and 0.84 for elastography and 0.82, 0.62 and 0.72 for ERUS. A combined staging algorithm was developed to identify tumours eligible for local resection. Based on MDT evaluation 32% of tumours later identified as pT0 or pT1 were treated with total mesorectal excision, even though a local excision might have sufficed. Combined ERUS and elastography evaluation would have significantly reduced this number to 9% (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.008).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Elastography may improve the staging of adenomas and early rectal cancer compared with <jats:styled-content style=\"fixed-case\">ERUS<\/jats:styled-content> alone. Combined <jats:styled-content style=\"fixed-case\">ERUS<\/jats:styled-content> and elastography assessment is likely to further improve the selection of patients for local resection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12764","type":"journal-article","created":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T09:01:51Z","timestamp":1409562111000},"page":"50-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Combined endorectal ultrasonography and strain elastography for the staging of early rectal cancer"],"prefix":"10.1111","volume":"17","author":[{"given":"J. E. R.","family":"Waage","sequence":"first","affiliation":[{"name":"Department of Surgery Haukeland University Hospital Bergen Norway"},{"name":"Department of Clinical Medicine University of Bergen Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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