{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:46:55Z","timestamp":1790099215534,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Several studies have suggested an increased lymph node yield, reduced locoregional recurrence and increased disease\u2010free survival after complete mesocolic excision (<jats:styled-content style=\"fixed-case\">CME<\/jats:styled-content>) for colorectal cancer. This review was undertaken to assess the use of <jats:styled-content style=\"fixed-case\">CME<\/jats:styled-content> for colon cancer by evaluating the technique and its clinical outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A literature search of publications was performed using PubMed and Medline. Only studies published in English were included. Studies assessed for quality and data were extracted by two independent reviewers. End\u2010points included number of lymph nodes per patient, quality of the plane of mesocolic excision, postoperative mortality and morbidity, 5\u2010year locoregional recurrence and 5\u2010year cancer\u2010specific survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 34 articles comprising 12 retrospective studies, nine prospective studies and 13 original articles including case series, observational studies and editorials. Of the prospective studies, four reported an increased lymph node harvest and a survival benefit. The others reported an improvement in the quality of the specimen as assessed by histopathological examination. Laparoscopic <jats:styled-content style=\"fixed-case\">CME<\/jats:styled-content> has the same oncological outcome as open surgery but completeness of excision during laparoscopy may be compromised for tumours in the transverse colon.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Studies demonstrate that <jats:styled-content style=\"fixed-case\">CME<\/jats:styled-content> removes significantly more tissue around the tumour including maximal lymph node clearance. There is little information on serious adverse events after <jats:styled-content style=\"fixed-case\">CME<\/jats:styled-content> and a long\u2010term survival benefit has not been proved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12793","type":"journal-article","created":{"date-parts":[[2014,10,5]],"date-time":"2014-10-05T12:39:06Z","timestamp":1412512746000},"page":"7-16","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Complete mesocolic excision in colorectal cancer: a systematic review"],"prefix":"10.1111","volume":"17","author":[{"given":"C.","family":"Kontovounisios","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kinross","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Rasheed","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Tekkis","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery Royal Marsden Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.55.2.74"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2007.04270.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.4834"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800710105"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(96)00532-9"},{"key":"e_1_2_7_7_1","first-page":"602","article-title":"More extensive nodal dissection improves survival for stages I to III of colon cancer: a population\u2010based study","volume":"244","author":"Chen SL","year":"2006","journal-title":"Ann Surg"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2008.01735.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-010-0609-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2010.02474.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.24.1448"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70181-5"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7518"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-012-2435-9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-012-2294-4"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03019.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002680010252"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6673-3"},{"key":"e_1_2_7_19_1","first-page":"1774","author":"Banister LH","journal-title":"The Anatomical Basis for Medicine and Surgery,"},{"key":"e_1_2_7_20_1","first-page":"148","article-title":"Alimentary tract. 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