{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T07:38:40Z","timestamp":1790667520456,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T00:00:00Z","timestamp":1421798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Strain elastography is a method for recording tissue hardness. Strain in different areas may be compared using strain ratio (<jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>). The aims of this study were to validate a previously proposed <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> cut\u2010off value of 1.25 for differentiating adenocarcinomas from adenomas and to compare the performance of endorectal ultrasonography (<jats:styled-content style=\"fixed-case\">ERUS<\/jats:styled-content>), strain elastography and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> in the same patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A prospective evaluation of 120 consecutive patients with rectal neoplasia, using a predetermined elastography strain ratio cut\u2010off value, was performed to differentiate adenomas from adenocarcinomas. <jats:styled-content style=\"fixed-case\">ERUS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> were performed according to standard routine at Haukeland University Hospital, defining T0 as adenomas and T1\u2013T4 as adenocarcinomas. Subsequent histopathology was used as the reference standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histopathological evaluation revealed 21 adenomas and 99 adenocarcinomas. Sensitivity, specificity and accuracy (with 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) were as follows: <jats:styled-content style=\"fixed-case\">ERUS<\/jats:styled-content>: 0.96 (0.90\u20130.99), 0.62 (0.40\u20130.80) and 0.90 (0.83\u20130.94); elastography <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content>: 0.96 (0.90\u20130.99), 0.86 (0.66\u20130.96) and 0.94 (0.88\u20130.97); and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>: 0.99 (0.94\u20131.00), 0.07 (0.00\u20130.31) and 0.87 (0.80\u20130.93).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study confirms that the elastography <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> assessment accurately differentiates sessile adenomas from adenocarcinomas. <jats:styled-content style=\"fixed-case\">SR<\/jats:styled-content> assessment has a superior ability to differentiate adenomas and adenocarcinomas when compared with <jats:styled-content style=\"fixed-case\">ERUS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> examination seems unable to recognize adenomas and should be interpreted with care when early\u2010stage rectal neoplasia is suspected.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12845","type":"journal-article","created":{"date-parts":[[2014,11,19]],"date-time":"2014-11-19T02:57:31Z","timestamp":1416365851000},"page":"124-131","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Endorectal ultrasonography, strain elastography and MRI differentiation of rectal adenomas and adenocarcinomas"],"prefix":"10.1111","volume":"17","author":[{"given":"J. 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