{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:46:57Z","timestamp":1788450417596,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T00:00:00Z","timestamp":1426809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Combined infliximab and sphincter\u2010sparing surgery can be effective in perianal fistula associated with Crohn's disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>). This study aimed to assess the efficacy of local surgery combined with infliximab on sustained fistula closure and to identify predictive factors for response after this combined treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Between 2000 and 2010, 81 patients with fistulising perianal <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> were included in this observational study. Drainage with a loose seton was followed by infliximab therapy. The primary end\u2010points were the rate of complete fistula closure and time required for this to occur.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The fistula was complex in 71 (88%) of the 81 patients. Local proctological surgery was carried out in 77 (95%), including seton drainage in 62 (80.5%) of these. This was continued for a median duration of 3.8\u00a0months and the patient then received infliximab therapy. The median follow\u2010up after treatment was 64\u00a0months (2\u2013263). Initial complete closure of the fistula occurred in 71 (88%) cases at a median interval of 12.4\u00a0months (1\u2013147) from the start of treatment. Recurrence was observed in 29 (41%) patients at a median interval of 38.5\u00a0months (2\u201348) from the start of treatment. They were treated again with combined treatment with successful closure in 19 (65.5%) patients. The total rate of closure of the fistula was 75.3%. Female gender, anal stenosis, rectovaginal and complex fistula formation were factors independently associated with failure of combined treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Seton drainage for several months combined with infliximab therapy is effective in closing the fistula in 75% of patients with complex perianal fistula formation associated with <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12851","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T12:29:42Z","timestamp":1417004982000},"page":"311-319","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["The results of seton drainage combined with anti\u2010<scp>TNF<\/scp>\u03b1 therapy for anal fistula in Crohn's 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