{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T10:44:47Z","timestamp":1776336287755,"version":"3.51.2"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,1,21]],"date-time":"2015-01-21T00:00:00Z","timestamp":1421798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Transanal endoscopic microsurgery (<jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content>) enables organ preservation after rectal tumour surgery. Its application is being expanded using adjuvant and neoadjuvant treatments. Our objective was to evaluate the changes over time in anorectal function, urinary symptoms and quality of life (QoL) in patients who had <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content> surgery for a rectal tumour.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Between September 2009 and October 2012, a consecutive series of 102 patients underwent <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content> at a single institution. Patients were asked to fill out standardized questionnaires at baseline and then at 6, 12, 26 and 52\u00a0weeks after surgery. The QoL among these patients was assessed using one generic (<jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D) and two disease\u2010specific [European Organization for Research and Treatment of Cancer (<jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">QLQ<\/jats:styled-content>\u2010C30 and <jats:styled-content style=\"fixed-case\">QLQ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>29] questionnaires. Anorectal and urinary symptoms were studied using the <jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>lo\u2010<jats:styled-content style=\"fixed-case\">RE<\/jats:styled-content>ctal Functional Outcome (<jats:styled-content style=\"fixed-case\">COREFO<\/jats:styled-content>) and the International Prostate Symptom Score (I\u2010<jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content>) questionnaires, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The response rate was 90% (92\/102 patients). Postoperative complications occurred in 14% (13\/92) of patients. The general QoL (as assessed using the <jats:styled-content style=\"fixed-case\">EQ<\/jats:styled-content>\u20105D) was lower 6 and 12\u00a0weeks after <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content> compared with baseline QoL (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) but returned towards baseline after 26\u00a0weeks. Anorectal function (determined using the <jats:styled-content style=\"fixed-case\">COREFO<\/jats:styled-content>) was worse 6\u00a0weeks postoperatively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01) but had normalized by 12\u00a0weeks. Urinary function (determined using the I\u2010<jats:styled-content style=\"fixed-case\">PSS<\/jats:styled-content>) was not affected at any time point after surgery. The total <jats:styled-content style=\"fixed-case\">COREFO<\/jats:styled-content> score and the American Society of Anesthesiologists (<jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>) score were correlated with the deterioration in QoL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study demonstrates that <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content> has a temporary and reversible impact on QoL and anorectal function. Intensive interrogation of QoL and function using appropriate questionnaires will help to define the role of organ\u2010preserving surgery for rectal cancer before and after chemoradiotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12858","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T00:36:07Z","timestamp":1418085367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Evaluation of quality of life and function at 1\u00a0year after transanal endoscopic microsurgery"],"prefix":"10.1111","volume":"17","author":[{"given":"R.","family":"Hompes","sequence":"first","affiliation":[{"name":"Oxford Colorectal Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Q.","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Oxford Colorectal Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6396-3977","authenticated-orcid":false,"given":"M. P.","family":"Gosselink","sequence":"additional","affiliation":[{"name":"Oxford Colorectal Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. W.","family":"van Dongen","sequence":"additional","affiliation":[{"name":"Oxford Colorectal Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J.","family":"Mortensen","sequence":"additional","affiliation":[{"name":"Oxford Colorectal Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Lindsey","sequence":"additional","affiliation":[{"name":"Oxford Colorectal Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Oxford Colorectal Centre Churchill Hospital Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,1,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6456"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300843"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08268-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)90207-W"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800830326"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.3.817"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.17.3062"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000171299.43954.ce"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-010-1347-9"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2006.01071.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7133.736"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/85.5.365"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2007.04.005"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-004-0638-9"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)36966-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(08)70129-3"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12125"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0942-z"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00704356"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181b14d2d"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004649900802"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305600"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-3166-2"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7584"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6252-7"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0031-y"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2006.01186.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8510(89)90092-4"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12858","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12858","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T15:10:09Z","timestamp":1696259409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12858"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,21]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/codi.12858"],"URL":"https:\/\/doi.org\/10.1111\/codi.12858","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,21]]},"assertion":[{"value":"2014-05-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-01-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}