{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T02:03:42Z","timestamp":1760061822258},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,20]],"date-time":"2015-05-20T00:00:00Z","timestamp":1432080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Pathological response to chemotherapy without pelvic irradiation is not well defined in rectal cancer. This study aimed to evaluate the objective pathological response to preoperative chemotherapy without pelvic irradiation in middle or low locally advanced rectal cancer (<jats:styled-content style=\"fixed-case\">LARC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2008 and 2013, 22 patients with middle or low <jats:styled-content style=\"fixed-case\">LARC<\/jats:styled-content> (T3\/4 and\/or N+ and circumferential resection margin &lt;\u00a02\u00a0mm) and synchronous metastatic disease or a contraindication to pelvic irradiation underwent rectal resection after preoperative chemotherapy. The pathological response of rectal tumour was analysed according to the R\u00f6del tumour regression grading (<jats:styled-content style=\"fixed-case\">TRG<\/jats:styled-content>) system. Predictive factors of objective pathological response (<jats:styled-content style=\"fixed-case\">TRG<\/jats:styled-content> 2\u20134) were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients underwent rectal surgery after a median of six cycles of preoperative chemotherapy. Of these, 20 (91%) had sphincter saving surgery and an R0 resection. Twelve (55%) patients had an objective pathological response (<jats:styled-content style=\"fixed-case\">TRG<\/jats:styled-content> 2\u20134), including one complete response. Poor response (<jats:styled-content style=\"fixed-case\">TRG<\/jats:styled-content> 0\u20131) to chemotherapy was noted in 10 (45%) patients. In univariate analyses, none of the factors examined was found to be predictive of an objective pathological response to chemotherapy. At a median follow\u2010up of 37.2\u00a0months, none of the 22 patients experienced local recurrence. Of the 19 patients with Stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> rectal cancer, 15 (79%) had liver surgery with curative intent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Preoperative chemotherapy without pelvic irradiation is associated with objective pathological response and adequate local control in selected patients with <jats:styled-content style=\"fixed-case\">LARC<\/jats:styled-content>. Further prospective controlled studies will address the question of whether it can be used as a valuable alternative to radiochemotherapy in <jats:styled-content style=\"fixed-case\">LARC<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12879","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T10:55:35Z","timestamp":1418986535000},"page":"491-498","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Pathological response of locally advanced rectal cancer to preoperative chemotherapy without pelvic irradiation"],"prefix":"10.1111","volume":"17","author":[{"given":"T.","family":"Bensignor","sequence":"first","affiliation":[{"name":"Department of Digestive and Oncologic Surgery H\u00f4pital Bic\u00eatre Assistance Publique H\u00f4pitaux de Paris Universit\u00e9 Paris\u2010Sud Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Brouquet","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncologic Surgery H\u00f4pital Bic\u00eatre Assistance Publique H\u00f4pitaux de Paris Universit\u00e9 Paris\u2010Sud Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Dariane","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncologic Surgery H\u00f4pital Bic\u00eatre Assistance Publique H\u00f4pitaux de Paris Universit\u00e9 Paris\u2010Sud Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Thirot\u2010Bidault","sequence":"additional","affiliation":[{"name":"Department of Digestive Oncology H\u00f4pital Bic\u00eatre Assistance Publique H\u00f4pitaux de Paris Universit\u00e9 Paris\u2010Sud Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Lazure","sequence":"additional","affiliation":[{"name":"Department of Pathology H\u00f4pital Bic\u00eatre Assistance Publique H\u00f4pitaux de Paris Universit\u00e9 Paris\u2010Sud Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Juli\u00e9","sequence":"additional","affiliation":[{"name":"Department of Pathology H\u00f4pital Ambroise Par\u00e9 Assistance Publique H\u00f4pitaux de Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Nordlinger","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology H\u00f4pital Ambroise Par\u00e9 Assistance Publique H\u00f4pitaux de Paris Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Penna","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncologic Surgery H\u00f4pital Bic\u00eatre Assistance Publique H\u00f4pitaux de Paris Universit\u00e9 Paris\u2010Sud Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Benoist","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncologic Surgery H\u00f4pital Bic\u00eatre Assistance Publique H\u00f4pitaux de Paris Universit\u00e9 Paris\u2010Sud Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060829"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa010580"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200111000-00008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70172-8"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.1329"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70097-3"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.40.1836"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181beb4d8"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.256"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70381-X"},{"key":"e_1_2_8_12_1","doi-asserted-by":"crossref","first-page":"abstract TPS196","DOI":"10.1200\/jco.2010.28.15_suppl.tps196","article-title":"Induction chemotherapy with or without chemoradiation in intermediate\u2010risk rectal cancer patients defined by magnetic resonance imaging (MRI): a GEMCAD study","volume":"28","author":"Fernandez\u2010Martos C","year":"2010","journal-title":"J Clin Oncol"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.25.8541"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"key":"e_1_2_8_15_1","first-page":"1S34","article-title":"[Recommendations for clinical practice. 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