{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:11:47Z","timestamp":1780963907968,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,6,22]],"date-time":"2015-06-22T00:00:00Z","timestamp":1434931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The study aimed to compare the rate of success and cost of anal fistula plug (<jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content>) insertion and endorectal advancement flap (<jats:styled-content style=\"fixed-case\">ERAF<\/jats:styled-content>) for anal fistula.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients receiving an <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">ERAF<\/jats:styled-content> for a complex single fistula tract, defined as involving more than a third of the longitudinal length of of the anal sphincter, were registered in a prospective database. A regression analysis was performed of factors predicting recurrence and contributing to cost.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seventy\u2010one patients (<jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> 31, <jats:styled-content style=\"fixed-case\">ERAF<\/jats:styled-content> 40) were analysed. Twelve (39%) recurrences occurred in the <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> and 17 (43%) in the <jats:styled-content style=\"fixed-case\">ERAF<\/jats:styled-content> group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>1.00). The median length of stay was 1.23 and 2.0\u00a0days (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), respectively, and the mean cost of treatment was \u20ac5439\u00a0\u00b1\u00a0\u20ac2629 and \u20ac7957\u00a0\u00b1\u00a0\u20ac5905 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.021), respectively. On multivariable analysis, postoperative complications, underlying inflammatory bowel disease and fistula recurring after previous treatment were independent predictors of <jats:italic>de novo<\/jats:italic> recurrence. It also showed that length of hospital stay \u2264\u00a01\u00a0day to be the most significant independent contributor to lower cost (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anal fistula plug and <jats:styled-content style=\"fixed-case\">ERAF<\/jats:styled-content> were equally effective in treating fistula\u2010in\u2010ano, but <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> has a mean cost saving of \u20ac2518 per procedure compared with <jats:styled-content style=\"fixed-case\">ERAF<\/jats:styled-content>. The higher cost for <jats:styled-content style=\"fixed-case\">ERAF<\/jats:styled-content> is due to a longer median length of stay.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12888","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T06:41:44Z","timestamp":1420008104000},"page":"619-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["An outcome and cost analysis of anal fistula plug insertion <i>vs<\/i> endorectal advancement flap for complex anal fistulae"],"prefix":"10.1111","volume":"17","author":[{"given":"O. M.","family":"Fisher","sequence":"first","affiliation":[{"name":"Department of Surgery University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. 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