{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T21:19:52Z","timestamp":1790630392026,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,3,20]],"date-time":"2015-03-20T00:00:00Z","timestamp":1426809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Identifying predictors for the recurrence of Crohn's disease (<jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>) after surgery to improve disease surveillance or targeted therapy is rational. The purpose of this study was to examine the relationship between myenteric plexitis (<jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>) and clinical or surgical recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Between 2000 and 2010, patients who underwent primary ileocaecal resection for <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content> at a single tertiary referral centre were identified. The histopathology was retrospectively reviewed for <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> at the resection margins. The severity of <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> was graded from 0 to 3 using a previously described classification. Information on demographics, surgical details and evidence of clinical or surgical recurrence was obtained from medical records.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 86 patients (49 women) of median age 31.5 (interquartile ratio 23.5\u201341.0) years. Seventy\u2010six and 77 specimens were assessable for proximal and distal <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>. Proximal <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> was present in 53 (69.7%) patients and was classified as mild, moderate or severe in 30 (39.5%), 14 (18.4) and nine (11.8%). <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> at the distal resection margin was present in 40 (51.9%). Forty (46.5%) patients developed clinical recurrence of whom 16 (18.6%) required surgery. Clinical factors that predicted recurrence included age &gt;\u00a040 (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.001) and the presence of an anastomosis (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.023). On univariate analysis severe plexitis (Grade 3 <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>) was also associated with surgical recurrence (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.035).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This retrospective study supports the association between <jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content> at the proximal resection margin and surgical recurrence.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12896","type":"journal-article","created":{"date-parts":[[2015,1,12]],"date-time":"2015-01-12T16:51:01Z","timestamp":1421081461000},"page":"304-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Myenteric plexitis at the proximal resection margin is a predictive marker for surgical recurrence of ileocaecal Crohn's disease"],"prefix":"10.1111","volume":"17","author":[{"given":"H.","family":"Misteli","sequence":"first","affiliation":[{"name":"Department of Cellular Pathology Department of Colorectal Surgery John Radcliffe Hospital Oxford University Hospital Oxford UK"},{"name":"Division of General Surgery University Hospital of Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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