{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T11:31:24Z","timestamp":1765279884314},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T00:00:00Z","timestamp":1437091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Elevation of the preoperative tumour markers in pseudomyxoma peritonei (PMP) is common and is a risk factor for recurrence. There has, however, been no documentation of the effect of complete tumour removal on tumour markers levels after cytoreductive surgery (<jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>) and hyperthermic intraperitoneal chemotherapy (<jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content>). The aim of the study was to compare the tumour markers 7\u00a0days after surgery in patients with elevated preoperative levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was an observational prospective study of patients with PMP of appendiceal origin treated in one of the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> National Referral Centres for this condition. Thirty patients [median age\u00a0=\u00a061 (range: 31\u201374) years; six men] with an elevated preoperative level of carcinoembryonic antigen (<jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content>), carbohydrate antigen 125 (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010125) and\/or carbohydrate antigen 19\u20109 (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>19\u20109) underwent repeated estimation, 7\u00a0days after <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HIPEC<\/jats:styled-content> for PMP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median preoperative <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> level of 12\u00a0\u03bcg\/l fell to 0.75\u00a0\u03bcg\/l postoperatively (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010125 fell from 45 to 31\u00a0<jats:styled-content style=\"fixed-case\">kU<\/jats:styled-content>\/l (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.183) and <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>19\u20109 fell from 134 to 37\u00a0<jats:styled-content style=\"fixed-case\">kU<\/jats:styled-content>\/l (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003). The <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> was raised in 22 (73%) of 30 patients preoperatively and in two (7%) of 30 patients 7\u00a0days after surgery (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The corresponding data for <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010125 were 18 (60%) and 13 (43%) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.196) and for <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>19\u20109 they were 24 (80%) and 16 (53%) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.028).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This is the first documentation of a reduction or normalization of <jats:styled-content style=\"fixed-case\">CEA<\/jats:styled-content> 7\u00a0days after <jats:styled-content style=\"fixed-case\">CRS<\/jats:styled-content>, but not for <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>19\u20109 or <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010125. This may indicate completeness of surgical resection and could aid selection for adjuvant therapy and predict prognosis. Long\u2010term follow\u2010up is, however, necessary to determine the significance of this observation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12924","type":"journal-article","created":{"date-parts":[[2015,2,20]],"date-time":"2015-02-20T15:38:27Z","timestamp":1424446707000},"page":"698-703","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Elevated tumour markers are normalized in most patients with pseudomyxoma peritonei 7\u00a0days after complete tumour removal"],"prefix":"10.1111","volume":"17","author":[{"given":"F.","family":"Di Fabio","sequence":"first","affiliation":[{"name":"Peritoneal Malignancy Institute and Colorectal Surgery Basingstoke and North Hampshire Hospitals Basingstoke UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Aston","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute and Colorectal Surgery Basingstoke and North Hampshire Hospitals Basingstoke UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute and Colorectal Surgery Basingstoke and North Hampshire Hospitals Basingstoke UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Chandrakumaran","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute and Colorectal Surgery Basingstoke and North Hampshire Hospitals Basingstoke UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Cecil","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute and Colorectal Surgery Basingstoke and North Hampshire Hospitals Basingstoke UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Moran","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute and Colorectal Surgery Basingstoke and North Hampshire Hospitals Basingstoke UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2007.04.002"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-916281"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1055-3207(03)00026-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2013.12.021"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annpat.2014.01.011"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.23329"},{"key":"e_1_2_9_8_1","first-page":"173","article-title":"Carbohydrate antigen 19\u20109 (Ca19\u20109) is an independent prognostic indicator in pseudomyxoma peritonei post cytoreductive surgery and perioperative intraperitoneal chemotherapy","volume":"4","author":"Koh J","year":"2013","journal-title":"J Gastrointest 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