{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T21:03:37Z","timestamp":1774127017874,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T00:00:00Z","timestamp":1438992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIHR UCL Biomedical Research Centre","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n Our aim was to determine whether the benefits of autologous skeletal\u2010muscle\u2010derived cell injection to treat obstetric anal incontinence are sustained at 5\u00a0years.<\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n An observational study was performed of 10 women suffering from obstetric anal incontinence refractory to non\u2010surgical therapy. Autologous skeletal\u2010muscle\u2010derived cells were injected into the external sphincter defect under ultrasound guidance. Incontinence diaries and quality of life questionnaires were obtained pre\u2010implantation and annually after implantation for 5\u00a0years. Anal physiology testing was performed before implantation and at 1, 2 and 5\u00a0years after implantation. The end\u2010points included were adverse events, Wexner incontinence scores, incontinence episodes, anal squeeze pressures and quality of life over 5\u00a0years. An independent statistician used multilevel linear regression to analyse changes in repeated measures over time. Any skewed distributions were log transformed prior to analysis.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n No procedure\u2010related adverse events occurred and haematological and biochemical parameters were normal during the 5\u2010year period. There were sustained significant improvements in the Wexner incontinence score and reduced frequency of defaecation and number of incontinence episodes (all comparisons\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001). Anal resting and squeeze pressures showed sustained improvement (all\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001) and quality of life improved overall (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001), including all submeasures studied (\n P\u00a0<\/jats:italic>\n <\n \u00a0<\/jats:italic>\n 0.001).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Autologous skeletal\u2010muscle\u2010derived cells to treat obstetric anal incontinence resulted in sustained improvement in incontinence episodes, physiological measurements of anal function and quality of life at 5\u00a0years.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/codi.12947","type":"journal-article","created":{"date-parts":[[2015,3,14]],"date-time":"2015-03-14T03:40:06Z","timestamp":1426304406000},"page":"794-801","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Autologous skeletal\u2010muscle\u2010derived cell injection for anal incontinence due to obstetric trauma: a 5\u2010year follow\u2010up of an initial study of 10 patients"],"prefix":"10.1111","volume":"17","author":[{"given":"A.","family":"Frudinger","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pfeifer","sequence":"additional","affiliation":[{"name":"General Surgery Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Paede","sequence":"additional","affiliation":[{"name":"B\u2010K Medical Quickborn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Kolovetsiou\u2010Kreiner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Marksteiner","sequence":"additional","affiliation":[{"name":"Innovacell Biotechnologie AG Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Halligan","sequence":"additional","affiliation":[{"name":"Centre for Medical Imaging University College London London 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for faecal incontinence in adults","volume":"7","author":"Brown SR","year":"2013","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2013.220"}],"container-title":["Colorectal 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