{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T13:54:44Z","timestamp":1780322084041,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The clinicopathological and virological characteristics of anal superficially invasive squamous\u2010cell carcinoma (<jats:styled-content style=\"fixed-case\">SISCCA<\/jats:styled-content>) were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Seventeen patients with a completely excised stage T1N0M0 anal squamous\u2010cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) were included in the study. The tumours were divided into superficially invasive and invasive. Patients with anal high\u2010grade squamous intraepithelial dysplasia, which corresponded to anal intraepithelial neoplasia (<jats:styled-content style=\"fixed-case\">AIN<\/jats:styled-content>) Grades 2 or 3, were used as a control group. Clinicopathological and virological characteristics were investigated. Overall survival and cancer recurrence\u2010free survival were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 17 patients, 12 (70.5%) were men. Ten (58.8%) were human immunodeficiency virus positive. Seven (41%) patients met the same diagnostic criteria as those recently proposed for anal <jats:styled-content style=\"fixed-case\">SISCCA<\/jats:styled-content>. According to the results obtained using the polymerase chain reaction, human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) 16 was the most commonly detected (94%) type of <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>. Twelve (70.6%) patients with an inadequate surgical margin around the tumour received adjuvant radiotherapy, including the two (11.7%) tumours that locally recurred, one of which was an anal <jats:styled-content style=\"fixed-case\">SISCCA<\/jats:styled-content>. Superficially invasive anal cancers differed from the other T1N0M0 anal carcinomas according to the clinical presentation and the absence of lymph\u2010vascular invasion (<jats:styled-content style=\"fixed-case\">LVI<\/jats:styled-content>). There were no differences in cancer recurrence\u2010free and overall survival rates between the superficially invasive and invasive groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anal <jats:styled-content style=\"fixed-case\">SISCCA<\/jats:styled-content>s have a low index of clinical suspicion, are associated with an absence of <jats:styled-content style=\"fixed-case\">LVI<\/jats:styled-content> and are linked to high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>. Prospective studies are needed to define the clinical behaviour of these anal tumours and to determine their best therapeutic strategy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12951","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T02:27:21Z","timestamp":1426645641000},"page":"965-972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Clinicopathological and virological characteristics of superficially invasive squamous\u2010cell carcinoma of the anus"],"prefix":"10.1111","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7231-9622","authenticated-orcid":false,"given":"R.","family":"Arana","sequence":"first","affiliation":[{"name":"Department of Pathology H\u00f4pital Saint\u2010Antoine H\u00f4pitaux Universitaires Paris Est, AP\u2010HP Paris France"},{"name":"Universit\u00e9 Pierre et Marie Curie \u2013 Paris 6 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.\u2010F.","family":"Fl\u00e9jou","sequence":"additional","affiliation":[{"name":"Department of Pathology H\u00f4pital Saint\u2010Antoine H\u00f4pitaux Universitaires Paris Est, AP\u2010HP Paris France"},{"name":"Universit\u00e9 Pierre et Marie Curie \u2013 Paris 6 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Si\u2010Mohamed","sequence":"additional","affiliation":[{"name":"Department of Virology H\u00f4pital Europ\u00e9en Georges Pompidou H\u00f4pitaux Universitaires Paris Ouest, AP\u2010HP Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bauer","sequence":"additional","affiliation":[{"name":"Department of Proctology Groupe Hospitalier Diaconesses Croix Saint\u2010Simon Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Etienney","sequence":"additional","affiliation":[{"name":"Department of Proctology Groupe Hospitalier Diaconesses Croix Saint\u2010Simon Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.2524"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.20126"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2014.07.030"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.LGT200570"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2010.02494.x"},{"key":"e_1_2_9_7_1","unstructured":"Th\u00e9saurus National de Canc\u00e9rologie Digestive (TNCD).http:\/\/www.tncd.org\/. 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