{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:14:25Z","timestamp":1791508465169,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The feasibility and outcome of sphincter\u2010saving resection for rectal cancer were assessed in patients previously treated by high\u2010dose radiotherapy for prostate cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Between 2000 and 2012, 1066 patients underwent rectal excision for rectal cancer. Of these, 236 were treated by conventional radiotherapy (45\u00a0Gy) and sphincter\u2010saving resection (Group A) and 12 were treated by external\u2010beam radiotherapy (<jats:styled-content style=\"fixed-case\">EBRT<\/jats:styled-content>) for prostate cancer (70\u00a0Gy) and sphincter\u2010saving resection (Group B) of whom five had a metachronous and seven a synchronous cancer. The end\u2010points were surgical morbidity, pelvic sepsis, reoperation and definitive stoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tumour characteristics were similar in both groups. Surgical morbidity (67% <jats:italic>vs<\/jats:italic> 25%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004), anastomotic leakage (50% <jats:italic>vs<\/jats:italic> 10%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001, and reoperation (50% <jats:italic>vs<\/jats:italic> 17%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011) were significantly higher in Group B. Multivariate analyses showed that <jats:styled-content style=\"fixed-case\">EBRT<\/jats:styled-content> for prostate cancer was the only independent factor for anastomotic leakage (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a05.12; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.45\u201318.08; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.011) and definitive stoma (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a010.56; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.02\u201339.92; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010dose radiotherapy for prostate cancer increases morbidity from rectal surgery and the risk of a permanent stoma. This suggests that a delayed coloanal anastomosis or a Hartmann procedure should be proposed as an alternative to low anterior resection in this population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12962","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T14:18:58Z","timestamp":1427897938000},"page":"973-979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Surgery for rectal cancer after high\u2010dose radiotherapy for prostate cancer: is sphincter preservation relevant?"],"prefix":"10.1111","volume":"17","author":[{"given":"E.","family":"Buscail","sequence":"first","affiliation":[{"name":"Department of Digestive Surgery and Universit\u00e9 Bordeaux Segalen CHU Bordeaux, Saint Andr\u00e9 Hospital Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Blondeau","sequence":"additional","affiliation":[{"name":"Department of Digestive 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