{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:45:39Z","timestamp":1788871539591,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Institute for Health Research University College London Hospitals Biomedical Research Centre"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      Systemic sclerosis (\n                      <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                      c) is a multisystem disorder of unknown aetiology leading to the deposition of excessive connective tissue in the skin, blood vessels and internal organs. Gastrointestinal involvement occurs in 90% of cases and the prevalence of faecal incontinence (\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      ) is 38%. This study comprises the largest case series assessing the efficacy of sacral nerve stimulation (\n                      <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>\n                      ) treatment for incontinence in this patient group.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      A retrospective analysis on prospectively collected data was performed on all\n                      <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>\n                      c patients from our two centres who had undergone\n                      <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>\n                      for\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Ten female patients of mean age of 54 (37\u201372)\u00a0years had temporary\n                      <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>\n                      performed. The mean duration of\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      was 13 (2\u201325)\u00a0years. All had passive\n                      <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>\n                      . Each patient had preprocedure anorectal physiology and endoanal ultrasound examinations documenting internal sphincter atrophy\/fragmentation or reduced anal resting pressure. Overall there was no statistically significant difference (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.57) in the total Wexner incontinence scores before (mean 15.1\u00a0\u00b1\u00a02.6\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      ) and during temporary\n                      <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>\n                      procedures (mean 13.1\u00a0\u00b1 3.6\n                      <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>\n                      ). Two patients with a significant improvement went on to have permanent\n                      <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>\n                      with only one achieving a favourable outcome at 1\u00a0year.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This study showed that\n                      <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>\n                      failed to reduce episodes of leakage in nine out of 10 patients with systemic sclerosis affected with incontinence.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.12969","type":"journal-article","created":{"date-parts":[[2015,4,7]],"date-time":"2015-04-07T12:34:09Z","timestamp":1428410049000},"page":"903-907","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Lack of effect of sacral nerve stimulation for incontinence in patients with systemic sclerosis"],"prefix":"10.1111","volume":"17","author":[{"given":"S. K.","family":"Butt","sequence":"first","affiliation":[{"name":"Neurogastroenterology Unit Royal Free and University College Hospital NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alam","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Unit Royal Free and University College Hospital NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Unit Royal Free and University College Hospital NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Krogh","sequence":"additional","affiliation":[{"name":"Department of Hepatology and Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Buntzen","sequence":"additional","affiliation":[{"name":"Department of Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Unit Royal Free and University College Hospital NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2006.02804.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker153"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750026434"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009742.2011.579575"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12063"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2009.06.002"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.399"},{"key":"e_1_2_9_9_1","volume-title":"Faecal incontinence. 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