{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T11:38:10Z","timestamp":1774352290419,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>According to the French <jats:styled-content style=\"fixed-case\">GRECCAR III<\/jats:styled-content> randomized trial, full mechanical bowel preparation (<jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content>) for rectal surgery decreases the rate of postoperative morbidity, in particular postoperative infectious complications, but <jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content> is not well tolerated by the patient. The aim of the present study was to determine whether a preoperative rectal enema (<jats:styled-content style=\"fixed-case\">RE<\/jats:styled-content>) might be an alternative to <jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An analysis was performed of 96 matched cohort patients undergoing rectal resection with primary anastomosis and protective ileostomy at two different university teaching hospitals, whose rectal cancer management was comparable except for the choice of preoperative bowel preparation (<jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">RE<\/jats:styled-content>). Prospective databases were retrospectively analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients were well matched for age, gender, body mass index and Charlson index. The surgical approach and cancer characteristics (level above anal verge, stage and use of neoadjuvant therapy) were comparable between the two groups. Anastomotic leakage occurred in 10% of patients having <jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content> and in 8% having <jats:styled-content style=\"fixed-case\">RE<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a01.00). Pelvic abscess formation (6% <jats:italic>vs<\/jats:italic> 2%, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.63) and wound infection (8% <jats:italic>vs<\/jats:italic> 15%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.55) were also comparable. Extra\u2010abdominal infection (13% <jats:italic>vs<\/jats:italic> 13%, <jats:italic>P<\/jats:italic>\u00a0=\u00a01.00) and non\u2010infectious abdominal complications such as ileus and bleeding (27% and 31%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.83) were not significantly different. Overall morbidity was comparable in the two groups (50% <jats:italic>vs<\/jats:italic> 54%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.83).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A simple <jats:styled-content style=\"fixed-case\">RE<\/jats:styled-content> before rectal surgery seems not to be associated with more postoperative infectious complications nor a higher overall morbidity than <jats:styled-content style=\"fixed-case\">MBP<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12974","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T12:55:10Z","timestamp":1429188910000},"page":"1007-1010","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Rectal enema is an alternative to full mechanical bowel preparation for primary rectal cancer surgery"],"prefix":"10.1111","volume":"17","author":[{"given":"O.","family":"Pittet","sequence":"first","affiliation":[{"name":"Department of Visceral Surgery University Hospital Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nocito","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Balke","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Duvoisin","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery University Hospital Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. A.","family":"Clavien","sequence":"additional","affiliation":[{"name":"Department of Visceral and Transplantation Surgery University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Demartines","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery University Hospital Lausanne Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Hahnloser","sequence":"additional","affiliation":[{"name":"Department of Visceral Surgery University Hospital Lausanne Lausanne Switzerland"},{"name":"Department of Visceral and Transplantation Surgery University Hospital Zurich Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318193425a"},{"key":"e_1_2_6_3_1","first-page":"CD001544","article-title":"Mechanical bowel preparation for elective colorectal surgery","author":"Guenaga KK","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_4_1","first-page":"CD001544","article-title":"Mechanical bowel preparation for elective colorectal surgery","author":"Guenaga KF","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181c0e75c"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5524"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(05)80008-2"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0000000000000066"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181fd8ea9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SLA.0000055222.90581.59"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0895-4356(94)90129-5"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.139.12.1359"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61905-9"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000013427"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(02)70367-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-005-0073-1"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9051-0"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318262a6cd"},{"key":"e_1_2_6_20_1","first-page":"CD002100","article-title":"Prophylactic anastomotic drainage for colorectal surgery","author":"Jesus EC","year":"2004","journal-title":"Cochrane Database Syst Rev"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12974","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12974","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:11:29Z","timestamp":1696360289000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12974"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,9]]},"references-count":19,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/codi.12974"],"URL":"https:\/\/doi.org\/10.1111\/codi.12974","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,9]]},"assertion":[{"value":"2014-08-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}