{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:14:49Z","timestamp":1787062489545,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T00:00:00Z","timestamp":1438992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The study determined the outcome of 1200 consecutive patients treated for peritoneal malignancy in one surgical unit over a 20\u2010year period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted of a custom designed prospective database of patients undergoing surgery for peritoneal malignancy since 1994. Patient demographics, tumour type, extent of surgery and outcome were recorded.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Between 1994 and January 2014 (when the 1200th case had undergone surgery) 2956 patients were referred with a diagnosis of peritoneal malignancy. Pseudomyxoma peritonei of appendiceal origin was the pathology in 956\/1200 (79.7%) patients. Other aetiologies included colorectal peritoneal metastases [89\/1200 (7.4%)], abdominal mesothelioma [65\/1200 (5.4%)] and miscellaneous [90\/1200 (7.5%)]. Overall 863\/1200 (71.9%) had complete cytoreduction, 294 (24.5%) had maximal tumour debulking and 43 (3.6%) had laparotomy only. The proportion undergoing complete cytoreduction per quartile of 300 patients was 60.7%, 65.0%, 77.0% and 80.3%. Laparotomy and biopsy fell from 6.4% in the first quartile to 2.7%, 1.7% and 1.3% in subsequent quartiles. The 30\u2010day mortality in the four quartiles was 3.0%, 1.0%, 0.7% and 0.7%. The 5\u2010year survival was 84% in the 636 patients with appendix tumours who had complete cytoreduction, 76% in the 38 with abdominal mesothelioma and 44% in the 60 with colorectal peritoneal metastases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A centralized approach facilitated high volume experience in a single centre with an increase in the completeness of surgical excision rates and a reduction in mortality and morbidity over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.12975","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T08:53:00Z","timestamp":1429174380000},"page":"772-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["The results of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in 1200 patients with peritoneal malignancy"],"prefix":"10.1111","volume":"17","author":[{"given":"B.","family":"Moran","sequence":"first","affiliation":[{"name":"Peritoneal Malignancy Institute North Hampshire Hospital Hampshire Hospital Foundation Trust Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Cecil","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute North Hampshire Hospital Hampshire Hospital Foundation Trust Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Chandrakumaran","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute North Hampshire Hospital Hampshire Hospital Foundation Trust Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute North Hampshire Hospital Hampshire Hospital Foundation Trust Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute North Hampshire Hospital Hampshire Hospital Foundation Trust Basingstoke UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Venkatasubramaniam","sequence":"additional","affiliation":[{"name":"Peritoneal Malignancy Institute North Hampshire Hospital Hampshire Hospital Foundation Trust Basingstoke 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