{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:22:16Z","timestamp":1740126136731,"version":"3.37.3"},"reference-count":14,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,10,9]],"date-time":"2015-10-09T00:00:00Z","timestamp":1444348800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009491","name":"St Mark's Hospital Foundation","doi-asserted-by":"crossref","award":["1140930"],"award-info":[{"award-number":["1140930"]}],"id":[{"id":"10.13039\/501100009491","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Sacral nerve stimulation (<jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>) may be offered to patients with constipation who have failed to improve with conservative treatment. The response to <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> is variable, with a significant loss of efficacy in some patients. An increased frequency of stimulation may improve the efficacy of <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> for faecal incontinence. This study aimed to see if alteration of the pulse width or frequency improved the outcome for those with constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Eleven patients with constipation currently being treated by <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> were recruited from three centres. They were randomized to five different protocols of stimulation each applied for 5\u00a0weeks. Group 1 used standard settings (pulse width 210\u00a0\u03bcs, frequency 14\u00a0Hz); in the other four groups (Groups 2\u20135) the pulse width and\/or frequency were halved or doubled. Patients and investigators were blinded to the group allocation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Cleveland Clinic constipation score varied significantly between the five groups. Group 1 achieved the lowest score mean (\u00b1\u00a0<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) 13.4 (\u00b1\u00a04.4) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03). The number of digitations per defaecation was the lowest in Group 4, 90\u00a0\u03bcs and 14\u00a0Hz (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). No other variable changed significantly. Standard settings were the most preferred by the recruited patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Alteration of pulse width or frequency of stimulation had no significant effect on the outcome of <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> for constipation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.12982","type":"journal-article","created":{"date-parts":[[2015,4,27]],"date-time":"2015-04-27T16:20:43Z","timestamp":1430151643000},"page":"990-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A double\u2010blinded randomized multicentre study to investigate the effect of changes in stimulation parameters on sacral nerve stimulation for constipation"],"prefix":"10.1111","volume":"17","author":[{"given":"G. P.","family":"Thomas","sequence":"first","affiliation":[{"name":"The Sir Alan Parks Department of Physiology St Mark's Hospital and Academic Institute Harrow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Duelund\u2010Jakobsen","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9883-6700","authenticated-orcid":false,"given":"T. C.","family":"Dudding","sequence":"additional","affiliation":[{"name":"The Sir Alan Parks Department of Physiology St Mark's Hospital and Academic Institute Harrow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Bradshaw","sequence":"additional","affiliation":[{"name":"The Sir Alan Parks Department of Physiology St Mark's Hospital and Academic Institute Harrow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. J.","family":"Nicholls","sequence":"additional","affiliation":[{"name":"The Sir Alan Parks Department of Physiology St Mark's Hospital and Academic Institute Harrow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Alam","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Thin","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. H.","family":"Knowles","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Laurberg","sequence":"additional","affiliation":[{"name":"Department of Surgical Gastroenterology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. J.","family":"Vaizey","sequence":"additional","affiliation":[{"name":"The Sir Alan Parks Department of Physiology St Mark's Hospital and Academic Institute Harrow UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.164"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8944"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(95)91799-3"},{"issue":"1","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S0022-5347(17)38751-7","article-title":"Neural stimulation for control of voiding dysfunction: a preliminary report in 22 patients with serious neuropathic voiding disorders","volume":"142","author":"Tanagho EA","year":"1989","journal-title":"J Urol"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181d64207"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6637"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8867"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02056950"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750025327"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520510012208"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2002.02278.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12418"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000095921.81600.4d"},{"issue":"2","key":"e_1_2_7_15_1","first-page":"35","article-title":"Efficacy of sacral nerve stimulation for treating slow transit constipation: a randomised double\u2010blind, placeno\u2010controlled, 2 phase crossover study","volume":"16","author":"Dinning P","year":"2014","journal-title":"Colorectal Dis"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.12982","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.12982","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T19:11:11Z","timestamp":1696360271000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.12982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,9]]},"references-count":14,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1111\/codi.12982"],"URL":"https:\/\/doi.org\/10.1111\/codi.12982","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"type":"print","value":"1462-8910"},{"type":"electronic","value":"1463-1318"}],"subject":[],"published":{"date-parts":[[2015,10,9]]},"assertion":[{"value":"2014-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-02-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}