{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T06:31:25Z","timestamp":1775025085973,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Anorectal manometry is the most common test used to explore anorectal disorders. The recent three\u2010dimensional high\u2010resolution anorectal manometry (3D\u2010HRAM) technique appears to be able to provide new topographic information. Our objective was to develop an automated analysis of 3D\u2010HRAM images to diagnose anal sphincter defects and compare the results with those of endoanal ultrasonography (EUS), which is considered to be the gold standard.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>All patients being tested in our department for faecal incontinence or dyschezia by 3D\u2010HRAM and EUS were eligible for the study. 3D\u2010HRAM was used to record resting and squeeze pressure, reflecting internal and external anal sphincter function, respectively. A software platform was designed to automatically analyse the 3D\u2010HRAM images and calculate a diagnostic score for any anal sphincter defect compared with EUS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 206 (91% female) patients of mean age of 54\u00a0years were included in the study. A sphincter defect was diagnosed by EUS in 130 (63%). The diagnostic scores from the 3D\u2010HRAM automated analysis for an internal anal sphincter defect showed a sensitivity of 65% and a specificity of 65%. For an external anal sphincter defect, the sensitivity was 43% and the specificity 87%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study developed a method based on 3D\u2010HRAM to automatically diagnose sphincter defects, allowing a systematic and comprehensive analysis of the test recordings. Compared with EUS, the 3D\u2010HRAM image analysis procedure revealed poor sensitivity and specificity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13017","type":"journal-article","created":{"date-parts":[[2015,6,5]],"date-time":"2015-06-05T13:23:48Z","timestamp":1433510628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Three\u2010dimensional high\u2010resolution anorectal manometry: does it allow automated analysis of sphincter defects?"],"prefix":"10.1111","volume":"17","author":[{"given":"A.","family":"Benezech","sequence":"first","affiliation":[{"name":"Service de Gastroent\u00e9rologie H\u00f4pital Nord Assistance Publique\u2010H\u00f4pitaux de Marseille Aix\u2010Marseille Universit\u00e9 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Behr","sequence":"additional","affiliation":[{"name":"Centre d'Investigation Clinique 1409 Assistance Publique\u2010H\u00f4pitaux de Marseille Aix\u2010Marseille Universit\u00e9 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Bouvier","sequence":"additional","affiliation":[{"name":"Service de Gastroent\u00e9rologie H\u00f4pital Nord Assistance Publique\u2010H\u00f4pitaux de Marseille Aix\u2010Marseille Universit\u00e9 Marseille France"},{"name":"Plateforme d'Interface Clinique CRN2M CNRS UMR 7286 Aix\u2010Marseille Universit\u00e9 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010C.","family":"Grimaud","sequence":"additional","affiliation":[{"name":"Service de Gastroent\u00e9rologie H\u00f4pital Nord Assistance Publique\u2010H\u00f4pitaux de Marseille Aix\u2010Marseille Universit\u00e9 Marseille France"},{"name":"Plateforme d'Interface Clinique CRN2M CNRS UMR 7286 Aix\u2010Marseille Universit\u00e9 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.","family":"Vitton","sequence":"additional","affiliation":[{"name":"Service de Gastroent\u00e9rologie H\u00f4pital Nord Assistance Publique\u2010H\u00f4pitaux de Marseille Aix\u2010Marseille Universit\u00e9 Marseille France"},{"name":"Plateforme d'Interface Clinique CRN2M CNRS UMR 7286 Aix\u2010Marseille Universit\u00e9 Marseille France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr\/27314678"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s003840100354"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2010.06.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00348.2010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01857.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12522"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12319"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000171417"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05450.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2012.18.4.450"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e318198caca"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1177\/028418519203300515","article-title":"Anal sphincter size measured by endosonography in healthy volunteers. Effect of age, sex, and parity","volume":"33","author":"Nielsen MB","year":"1992","journal-title":"Acta Radiol"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-28032014000300006"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312233292601"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92213-6"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.34.5.685"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02553822"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234563"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13017","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T03:03:04Z","timestamp":1696302184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,11]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1111\/codi.13017"],"URL":"https:\/\/doi.org\/10.1111\/codi.13017","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,11]]},"assertion":[{"value":"2015-02-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}