{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T20:48:57Z","timestamp":1781556537152,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,7,17]],"date-time":"2015-07-17T00:00:00Z","timestamp":1437091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Asan Institute for Life Sciences","award":["2014-596"],"award-info":[{"award-number":["2014-596"]}]},{"DOI":"10.13039\/501100003725","name":"Korea Research Foundation","doi-asserted-by":"crossref","award":["2013R1A2A1A03070986"],"award-info":[{"award-number":["2013R1A2A1A03070986"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>) with microsatellite instability (<jats:styled-content style=\"fixed-case\">MSI<\/jats:styled-content>) is characterized by frequent poor differentiation or mucinous histology. The purpose of this study was to evaluate the association of <jats:styled-content style=\"fixed-case\">MSI<\/jats:styled-content> with clinicopathological features and the oncological outcome in patients with a mucinous component.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> tissue samples were analysed for histology and <jats:styled-content style=\"fixed-case\">MSI<\/jats:styled-content>. Patients were grouped according to the mucinous content of the tumour, as follows: &gt;\u00a050%, mucinous adenocarcinoma (<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content>); \u2264\u00a050%, adenocarcinoma with mucinous component (<jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>); none, nonmucinous adenocarcinoma (<jats:styled-content style=\"fixed-case\">NMA<\/jats:styled-content>). Clinicopathological parameters and survival were compared between patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2025 patients, 84 (4%) had <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> and 124 (6%) had <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content>. In addition, 202 (10%) had <jats:styled-content style=\"fixed-case\">MSI<\/jats:styled-content>. Patients with <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content> tended to have a younger age of onset, right\u2010colon predilection, large\u2010sized tumour and high frequency of <jats:styled-content style=\"fixed-case\">MSI<\/jats:styled-content> compared with those with <jats:styled-content style=\"fixed-case\">NMA<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content> patients with <jats:styled-content style=\"fixed-case\">MSI<\/jats:styled-content> showed a trend towards right\u2010colon predilection and infrequent lymph\u2010node metastasis compared with those with microsatellite stability (<jats:styled-content style=\"fixed-case\">MSS<\/jats:styled-content>;<jats:italic> P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.005\u20130.03). There were no survival differences between the three groups, but patients with <jats:styled-content style=\"fixed-case\">MSI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> demonstrated lower 4\u2010year recurrence and better overall survival rates than those with <jats:styled-content style=\"fixed-case\">MSS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.018 and <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.046, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinicopathological features of <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> were similar and closely associated with <jats:styled-content style=\"fixed-case\">MSI<\/jats:styled-content> status. Although the prognoses of <jats:styled-content style=\"fixed-case\">AMC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> were no different from that of <jats:styled-content style=\"fixed-case\">NMA<\/jats:styled-content>, survival of patients with an <jats:styled-content style=\"fixed-case\">MSI<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> tumour was significantly better than for those with <jats:styled-content style=\"fixed-case\">MSS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MA<\/jats:styled-content> tumours.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13027","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T16:52:55Z","timestamp":1434732775000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Clinical implications of mucinous components correlated with microsatellite instability in patients with colorectal cancer"],"prefix":"10.1111","volume":"17","author":[{"given":"Y. S.","family":"Yoon","sequence":"first","affiliation":[{"name":"Department of Surgery University of Ulsan College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Ulsan College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010M.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Ulsan College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Ulsan College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. W.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Ulsan College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. J.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Ulsan College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010B.","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Ulsan College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Ulsan College of Medicine Asan Medical Center Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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