{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T18:36:11Z","timestamp":1789842971468,"version":"4.0.1"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,9,11]],"date-time":"2015-09-11T00:00:00Z","timestamp":1441929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Parastomal hernia (<jats:styled-content style=\"fixed-case\">PSH<\/jats:styled-content>) is the most common complication of an end\u2010colostomy and about one\u2010quarter of patients need operative repair, which is often unsuccessful. A randomized trial was carried out to compare the results of using mesh or no mesh at the time of formation of a colostomy with the clinical identification of <jats:styled-content style=\"fixed-case\">PSH<\/jats:styled-content> as the primary outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this two\u2010centre randomized trial (Oslo University Hospital and Sykehuset Innlandet Hospital Trust, Norway), patients with rectal cancer undergoing open pelvic surgery were randomized to receive a retromuscular synthetic mesh (study group, <jats:italic>n<\/jats:italic> = 32) or no mesh (control group, <jats:italic>n<\/jats:italic> = 26) at the time of end\u2010colostomy formation. Postoperative follow up was not blinded and included clinical examination and routine <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median period of follow up was 40 (range: 84) months. There were no differences in demographic variables or complications between the study and control groups. <jats:styled-content style=\"fixed-case\">PSH<\/jats:styled-content> developed in two patients of the study group and in 12 of the control group [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a00.04 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.01\u20130.30) and hazard ratio 0.134 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.030\u20130.603); <jats:italic>P\u00a0<\/jats:italic>&lt;\u00a00.001]. The number needed to treat to avoid one <jats:styled-content style=\"fixed-case\">PSH<\/jats:styled-content> was 2.5 patients. <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> demonstrated an increase over time in the size of the fascial orifice in patients with <jats:styled-content style=\"fixed-case\">PSH<\/jats:styled-content> without mesh prophylaxis, in contrast to a stable size in patients with mesh and in the control patients who did not develop <jats:styled-content style=\"fixed-case\">PSH<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The retromuscular insertion of synthetic mesh at the time of formation of an end\u2010colostomy reduced the risk of <jats:styled-content style=\"fixed-case\">PSH<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13065","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T19:07:51Z","timestamp":1436900871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Prophylactic mesh at end\u2010colostomy construction reduces parastomal hernia rate: a randomized trial"],"prefix":"10.1111","volume":"17","author":[{"given":"J. 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