{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:18:22Z","timestamp":1769815102236,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Pathological complete response (yp<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content>) after neoadjuvant treatment for rectal cancer is associated with favourable survival and a low rate of local recurrence. The aim of the study was to assess the incidence of yp<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> among patients with advanced rectal cancer treated with neoadjuvant chemoradiotherapy and curative resection and to explore factors associated with survival.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>From 2000 to 2009, 1384 patients enrolled in the national population\u2010 based colorectal cancer registry of Norway with advanced T3 and T4 rectal cancer with N0\u20132, M0 received neoadjuvant long\u2010course (chemo)radiation. The duration of follow\u2010up was a median of 5\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>yp<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> was achieved in 147 (10.6%) patients. The estimated 5\u2010year overall survival rate was 87% (confidence interval\u00a0\u00b1\u00a05.4) among yp<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> and 67% among non\u2010yp<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> (confidence interval\u00a0\u00b1\u00a02.7) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001). Distant metastasis developed in 12 (8%) of 147 and 328 (26.5%) of 1237 patients respectively (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). In a Cox proportional hazards ratio model the effect of yp<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> on survival was adjusted for age [hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) 1.056, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0001], metachronous metastasis (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 4.7, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0001), local recurrence (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 4.3, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0001) and surgical procedure (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 1.48, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.0001). The independent effect of yp<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 0.65, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.041) on survival almost disappeared compared with the univariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rate of yp<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> in advanced rectal cancer was about 10%. This phenomenon seems to occur in tumours with a low risk of metastasizing. The contribution of neoadjuvant therapy to yp<jats:styled-content style=\"fixed-case\">CR<\/jats:styled-content> on survival was small or absent.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13072","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T06:36:59Z","timestamp":1437547019000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["The outcome and the frequency of pathological complete response after neoadjuvant radiotherapy in curative resections for advanced rectal cancer: a population\u2010based study"],"prefix":"10.1111","volume":"18","author":[{"given":"H. H.","family":"Wasmuth","sequence":"first","affiliation":[{"name":"Department of Gastrointestinal Surgery St Olavs Hospital Trondheim University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. C.","family":"Rekstad","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery St Olavs Hospital Trondheim University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Tran\u00f8","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery St Olavs Hospital Trondheim University Hospital Trondheim Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70172-8"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31827541e2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.20340"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.8702"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2007.12.019"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181f3f1b1"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9112"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2005.00924.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5576"},{"key":"e_1_2_9_11_1","unstructured":"Kreftregisteret.\u00c5rsrapport fra colorectalcancer registeret.2013 Oslo Norway.www.kreftregisteret.\/no\/Generelt\/Nyheter\/Arsrapport-fra-colorectalcancerregisteret-2013(accessed October 2013)."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92612-7"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.037"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.15.3858"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.24247"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2013.03.017"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2011.02.024"},{"key":"e_1_2_9_18_1","volume-title":"Nasjonalt handlingsprogram med retningslinjer for diagnostikk, behandling og oppf\u00f8lging av tykk og endetarmskreft","author":"Helsedirektoratet","year":"2013"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70097-3"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2010.02360.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12317"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0374-z"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3181b91e63"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-012-2832-2"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.7739"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/145749690809700305"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2013.12.012"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.7176"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e3182a84eba"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13072","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T03:55:24Z","timestamp":1694663724000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/codi.13072"],"URL":"https:\/\/doi.org\/10.1111\/codi.13072","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2014-09-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}