{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T18:27:21Z","timestamp":1788287241391,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:00:00Z","timestamp":1456963200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Makarna Edvin Erikssons Foundation"},{"DOI":"10.13039\/100012538","name":"Swedish Cancer Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012538","id-type":"DOI","asserted-by":"crossref"}]},{"name":"ALF grants in Uppsala University"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Adhesions are the most common cause of small bowel obstruction (<jats:styled-content style=\"fixed-case\">SBO<\/jats:styled-content>). The costs of hospitalization and surgery for <jats:styled-content style=\"fixed-case\">SBO<\/jats:styled-content> are substantial for the health\u2010care system. The adhesion\u2010limiting potential of icodextrin has been shown in patients undergoing surgery for gynaecological diseases. A randomized, multicentre trial in colorectal cancer surgery started in 2009 with the aim of evaluating whether icodextrin could reduce the long\u2010term risk of surgery for <jats:styled-content style=\"fixed-case\">SBO<\/jats:styled-content>. Because of some concerns about complications (especially anastomotic leakage) after icodextrin use, a preplanned interim analysis of morbidity and mortality was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with colorectal cancer without metastasis were randomized 1:1 to receive standard surgery, with or without instillation of icodextrin in the abdominal cavity. For the first 300 patients, the 30\u2010day follow\u2010up data were collected from the Swedish ColoRectal Cancer Registry (<jats:styled-content style=\"fixed-case\">SCRCR<\/jats:styled-content>). Pre\u2010, per\u2010 and postoperative data, morbidity and mortality were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 300 randomized patients, 288 had a data file in the <jats:styled-content style=\"fixed-case\">SCRCR<\/jats:styled-content>. Twelve patients did not have cancer and another five did not have a resection, leaving 283 for analysis. The authors were blinded to the randomization groups. Demographic data were similar in both groups. The overall complication rate was 24% in Group 1 and 23% in Group 2 (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.89). Four cases of anastomotic leakage were reported in Group 1 and five were reported in Group 2 (<jats:italic>P\u00a0<\/jats:italic>=\u00a01.0). Mortality, intensive care unit (<jats:styled-content style=\"fixed-case\">ICU<\/jats:styled-content>) stay and re\u2010operations did not differ between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The pre\u2010planned safety analysis of the first 300 patients enrolled in this randomized trial did not show any differences in adverse effects related to the use of icodextrin. All data were gathered from the <jats:styled-content style=\"fixed-case\">SCRCR<\/jats:styled-content>, giving us a strong message that we can continue to include patients in the trial.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13095","type":"journal-article","created":{"date-parts":[[2015,8,20]],"date-time":"2015-08-20T16:43:35Z","timestamp":1440089015000},"page":"295-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Role of icodextrin in the prevention of small bowel obstruction. Safety randomized patients control of the first 300 in the <scp>ADEPT<\/scp> trial"],"prefix":"10.1111","volume":"18","author":[{"given":"T.","family":"Sakari","sequence":"first","affiliation":[{"name":"Department of Surgery G\u00e4vle Hospital and Centre for Research and Development Uppsala University\/Count Council of G\u00e4vleborg G\u00e4vleborg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sj\u00f6dahl","sequence":"additional","affiliation":[{"name":"Department of Surgery University Hospital Link\u00f6ping Link\u00f6ping Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"P\u00e5hlman","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Karlbom","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences Uppsala University Uppsala 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