{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T08:46:17Z","timestamp":1789461977059,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T00:00:00Z","timestamp":1446854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Danish Agency for Sciences, Technology and Innovation"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This randomized single\u2010blinded crossover study aimed to investigate whether bilateral sacral nerve stimulation (<jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>) is more efficient than unilateral stimulation for faecal incontinence (<jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> who responded during a unilateral test stimulation, with a minimum improvement of 50% were eligible. Twenty\u2010seven patients who were accepted to enter the trial were bilaterally implanted with two permanent leads and pacemakers. Patients were randomized into three periods of 4\u00a0weeks\u2019 stimulation including unilateral right, unilateral left and bilateral stimulation. Symptoms scores and bowel habit diaries were collected at baseline and in each study period. A 1\u2010week washout was introduced between each study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010seven (25 female) patients with a median age of 63 (36\u201384) years were bilaterally implanted from May 2009 to June 2012. The median number of episodes of <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> per 3\u00a0weeks significantly decreased from 17 (3\u201354) at baseline to 2 (0\u201320) during stimulation on the right side, 2 (0\u201342) during stimulation on the left side and 1 (0\u201325) during bilateral stimulation. The Wexner incontinence score improved significantly from a median of 16 (10\u201320) at baseline to 9 (0\u201314) with right\u2010side stimulation, 10 (0\u201315) with left\u2010side stimulation and 9 (0\u201314) with bilateral stimulation. The differences between unilateral right or unilateral left and bilateral stimulation were non\u2010significant, for <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> episodes (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.3) or for Wexner incontinence score (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.9).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Bilateral <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> therapy for <jats:styled-content style=\"fixed-case\">FI<\/jats:styled-content> is not superior to standard unilateral stimulation in the short term. Equal functional results can be obtained regardless of the side of implantation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13111","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T02:22:48Z","timestamp":1441851768000},"page":"1085-1093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Bilateral compared with unilateral sacral nerve stimulation for faecal incontinence: results of a randomized, single\u2010blinded crossover study"],"prefix":"10.1111","volume":"17","author":[{"given":"J.","family":"Duelund\u2010Jakobsen","sequence":"first","affiliation":[{"name":"Surgical Research Unit Department of Surgery P Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Buntzen","sequence":"additional","affiliation":[{"name":"Surgical Research Unit Department of Surgery P Aarhus University Hospital Aarhus 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