{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:29:35Z","timestamp":1790839775815,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T00:00:00Z","timestamp":1456963200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002736","name":"Covidien","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Permacol<jats:sup>\u2122<\/jats:sup> collagen paste (Permacol paste) is a new option for the treatment of anorectal fistula. It functions by filling the fistula tract with an acellular crosslinked porcine dermal collagen matrix suspension. The MASERATI 100 study group was set up to evaluate the clinical outcome of Permacol paste in the treatment of anorectal fistula. This paper reports the results from the initial 30 patients enrolled in the MASERATI 100 prospective, observational clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients (<jats:italic>N\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>30) with anal fistula presenting to 10 European academic surgical units were treated with a sphincter\u2010preserving technique using Permacol paste. Fistula healing was assessed at 1, 3, 6 and 12\u00a0months after treatment, with the primary end\u2010point of fistula healing at 6\u00a0months post\u2010surgery. Faecal continence and patient satisfaction were recorded at each follow\u2010up visit and adverse events were monitored throughout the follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 28 patients with data at 6\u00a0months post\u2010surgery, 15 (54%) were healed, and the healing rate was maintained at 12\u00a0months. Healing after treatment with Permacol paste was similar for intersphincteric to transsphincteric fistulae and primary or recurrent fistulae. Only one patient exhibited an adverse event (perianal abscess) that was possibly related to the treatment. At the last outpatient visit, over 60% of patients were satisfied or very satisfied with the operation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Permacol paste is shown to be effective in treating primary and recurrent cryptoglandular anorectal fistula with minimal unwanted side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13112","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T14:10:31Z","timestamp":1441894231000},"page":"286-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A prospective multicentre observational study of Permacol<sup>\u2122<\/sup> collagen paste for anorectal fistula: preliminary results"],"prefix":"10.1111","volume":"18","author":[{"given":"P.","family":"Giordano","sequence":"first","affiliation":[{"name":"Colorectal Department Whipps Cross University Hospital Barts Health London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Sileri","sequence":"additional","affiliation":[{"name":"University of Rome Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Buntzen","sequence":"additional","affiliation":[{"name":"Department of Surgery Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stuto","sequence":"additional","affiliation":[{"name":"General Surgery Department Ospedale Santa Maria degli Angeli Pordenone Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nunoo\u2010Mensah","sequence":"additional","affiliation":[{"name":"Department of Colorectal Surgery King's College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lenisa","sequence":"additional","affiliation":[{"name":"Surgery Unit San Pio X Hospital Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Singh","sequence":"additional","affiliation":[{"name":"Leicester General Hospital Leicester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Thorlacius\u2010Ussing","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery Aalborg University Hospital Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Griffiths","sequence":"additional","affiliation":[{"name":"NUTH Foundation Trust Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Ziyaie","sequence":"additional","affiliation":[{"name":"Ninewells Hospital and Medical School Dundee Scotland UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12440"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318223c894"},{"key":"e_1_2_8_4_1","first-page":"876","article-title":"The role of fibrin glue in the treatment of high and low fistulas in ano","volume":"7","author":"Mishra A","year":"2013","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1553350613508018"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2009.01933.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12391"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-011-1350-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2012.03192.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6708-9"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-7247-0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gcb.2008.09.003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2004.00676.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e318206043e"},{"key":"e_1_2_8_15_1","first-page":"608","article-title":"Armend'ariz P, de Miguel M. 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