{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:18Z","timestamp":1787014038758,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T00:00:00Z","timestamp":1462233600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      This study compared the efficacy of topical captopril with topical diltiazem in the treatment of chronic anal fissure (\n                      <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>\n                      Fifty patients aged between 15 and 75\u00a0years with\n                      <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>\n                      were included in a prospective randomized, double\u2010blind clinical trial. They were randomly allocated to either captopril (0.5%) cream or diltiazem (2%) cream in a dose of 2\u00a0cm of cream on the perianal skin every 12\u00a0h for 8\u00a0weeks. The intensity of pain upon defaecation was evaluated every 10\u00a0days using a visual analogue scale. Bleeding on defaecation, pruritus and the presence of perianal irritation were also recorded before and during the trial.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The average pain scores were lower in the diltiazem group on the 20th and 30th days. From day 40 to the end of the trial the average pain scores of the two groups did not differ significantly. There were no significant differences in bleeding or perianal irritation between the groups, but the incidence of pruritus was considerably higher in the captopril group, and at the end of the trial 45.8% of the patients in this group still suffered from pruritus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Topical captopril and diltiazem were found to be equally effective in the management of pain, bleeding and perianal irritation due to\n                      <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>\n                      , but due to the high incidence of pruritus observed with topical captopril this medication is not recommended for the treatment of\n                      <jats:styled-content style=\"fixed-case\">CAF<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.13147","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T19:46:04Z","timestamp":1444679164000},"page":"510-516","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Comparison of captopril (0.5%) cream with diltiazem (2%) cream for chronic anal fissure: a prospective randomized double\u2010blind two\u2010centre clinical trial"],"prefix":"10.1111","volume":"18","author":[{"given":"S.","family":"Ala","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy Mazandaran University of Medical Sciences Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Enayatifard","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Faculty of Pharmacy Mazandaran University of Medical Sciences Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Alvandipour","sequence":"additional","affiliation":[{"name":"Department of Surgery Imam Khomeini General Hospital affiliated to Mazandaran University of Medical Sciences Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Qobadighadikolaei","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy Mazandaran University of Medical Sciences Sari Mazandaran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.suc.2009.09.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-011-0683-7"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1015-9584(08)60078-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-007-0355-9"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-003-0079-5"},{"key":"e_1_2_8_7_1","first-page":"CD003431","article-title":"Non surgical therapy for anal fissure","volume":"2","author":"Nelson RL","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-003-0430-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234220"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4155\/cli.14.86"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236630"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.2001.01736.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02234624"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2002.00294.x"},{"key":"e_1_2_8_15_1","first-page":"1014","article-title":"Topical diltiazem is superior to topical lignocaine in the treatment of chronic anal fissure: results of a prospective comparative study","volume":"6","author":"Hanumanthappa MB","year":"2012","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2013.01.010"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6365-z"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2002.00376.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1323.2001.02042.x"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1463-1318.2003.00440.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595-006-3431-2"},{"key":"e_1_2_8_22_1","first-page":"379","article-title":"Comparison of topical glyceril trinitrate with diltiazem ointment for treatment of chronic anal fissure: a randomized clinical trial","volume":"80","author":"Sanei B","year":"2009","journal-title":"Ann Ital Chir"},{"key":"e_1_2_8_23_1","first-page":"614","article-title":"Topical diltiazem hydrochloride and glyceryl trinitrate in the treatment of chronic anal fissure","volume":"19","author":"Jawaid M","year":"2009","journal-title":"J Coll Physicians Surg Pak"},{"key":"e_1_2_8_24_1","first-page":"438","article-title":"Topical diltiazem vs. topical glyceril trinitrate in the treatment of chronic anal fissure: a prospective, randomized, double\u2010blind trial","volume":"75","author":"Ala S","year":"2012","journal-title":"Acta Gastroenterol Belg"},{"key":"e_1_2_8_25_1","first-page":"1747","article-title":"Topical diltiazem versus topical glyceryl trinitrate (GTN) in the treatment of chronic anal fissure: prospective study","volume":"3","author":"Suvarna R","year":"2012","journal-title":"Int J Biol Med Res"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.103366"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-013-0986-y"},{"key":"e_1_2_8_28_1","first-page":"366","volume-title":"The United States Pharmacopeia and National Formulary (USP 29\/NF24)","author":"Anonymous","year":"2006"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01527-2"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.03.056"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00115.2005"},{"key":"e_1_2_8_32_1","first-page":"1071","volume-title":"Martindale: The Complete Drug Reference","author":"Sweetman SC","year":"2007"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236691"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.44.5.727"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02236977"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13147","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:08:03Z","timestamp":1694650083000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1111\/codi.13147"],"URL":"https:\/\/doi.org\/10.1111\/codi.13147","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"2015-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-07-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}