{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:24:14Z","timestamp":1787880254980,"version":"build-2784847793"},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,4]],"date-time":"2016-01-04T00:00:00Z","timestamp":1451865600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Anal intraepithelial neoplasia precedes the development of anal squamous cell carcinoma. Detection of the lesion is essential to management. This paper describes a prospective study to detect and ablate anal squamous intraepithelial lesions (<jats:styled-content style=\"fixed-case\">SIL<\/jats:styled-content>s) using white light narrow band imaging (<jats:styled-content style=\"fixed-case\">NBI<\/jats:styled-content>) and <jats:styled-content style=\"fixed-case\">NBI<\/jats:styled-content> with acetic acid (<jats:styled-content style=\"fixed-case\">NBIA<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Sixty patients with abnormal anal cytology and risk factors for anal dysplasia underwent examination of the anoderm with a high definition gastroscope and <jats:styled-content style=\"fixed-case\">NBIA<\/jats:styled-content>. Targeted biopsies were taken and the lesions were ablated and characterized histopathologically. Visualization of the anal transitional zone was facilitated by retroflexion and examination through a disposable anoscope.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Targeted biopsies were taken from lesions in 58 patients. No lesion was seen in two patients. Histopathology showed <jats:styled-content style=\"fixed-case\">SIL<\/jats:styled-content> in 48 (80.0%) of 60 biopsies. One biopsy showed lymphoid aggregates. Biopsies in nine (15%) of the 60 patients showed normal mucosa. Lesions were seen in white light in 27 (45%) of the 60 cases, <jats:styled-content style=\"fixed-case\">NBI<\/jats:styled-content> in 39 (65%) and <jats:styled-content style=\"fixed-case\">NBIA<\/jats:styled-content> in 57 (95%). There was no major morbidity. Sensitivity analysis showed that all methods were significantly different from each other.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Anal <jats:styled-content style=\"fixed-case\">SIL<\/jats:styled-content> in the anal transitional zone and anal canal can be identified by <jats:styled-content style=\"fixed-case\">NBIA<\/jats:styled-content>. Patient selection influences findings. Limitations include small sample size and non\u2010randomization.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13170","type":"journal-article","created":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T08:19:10Z","timestamp":1446625150000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Detection of anal dysplasia is enhanced by narrow band imaging and acetic acid"],"prefix":"10.1111","volume":"18","author":[{"given":"M. D.","family":"Inkster","sequence":"first","affiliation":[{"name":"Departments of Gastroenterology\/Hepatology and Colorectal Surgery, Digestive Disease Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. O.","family":"Wiland","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Wu","sequence":"additional","affiliation":[{"name":"Departments of Gastroenterology\/Hepatology and Colorectal Surgery, Digestive Disease Institute Cleveland Clinic Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,4]]},"reference":[{"issue":"289","key":"e_1_2_9_2_1","first-page":"1","article-title":"The anal transitional zone","volume":"95","author":"Fenger C","year":"1987","journal-title":"Acta Pathol Microbiol Immunol Scand"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90830-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02051199"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1214942"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1244038"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1443-1661.2011.01153.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2012.07182.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00795-011-0541-8"},{"key":"e_1_2_9_10_1","unstructured":"DekkerE BergmanJ NeuhausHet\u00a0al.NBI Atlas.Tokyo Japan: Olympus 2006 F1183SB\u20101106."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.LGT200570"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-2042-8"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13170","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13170","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/codi.13170","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13170","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T03:56:02Z","timestamp":1694663762000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/codi.13170"],"URL":"https:\/\/doi.org\/10.1111\/codi.13170","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"2015-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-01-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}