{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T02:41:36Z","timestamp":1772160096850,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T00:00:00Z","timestamp":1472774400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Anal melanoma is a rare malignancy with a poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>All patients with a diagnosis of anal melanoma treated at a single institution between 2000 and 2012 were identified and their treatment and outcome were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Sixteen patients had a median survival of 2.9\u00a0years. Fourteen had Stage I or\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      disease with a median survival of 4.0\u00a0years and progression\u2010free survival of 1.5\u00a0years. When used for disease staging, whole body positron emission tomography\/\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      identified an additional three sites of metastasis in five patients compared with\n                      <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\n                      of the chest, abdomen and pelvis. Surgery involved wide local excision or abdominoperineal excision with respective local recurrence rates of 50% and 66%. Eleven patients underwent testing for c\u2010Kit mutations, of whom five were positive. Four of these were treated with the tyrosine kinase inhibitor imatinib, and showed rapid response of metastases outside the central nervous system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The outcome of this malignancy remains poor.\n                      <jats:styled-content style=\"fixed-case\">PET<\/jats:styled-content>\n                      is the modality of choice for disease staging. Testing tumours for c\u2010Kit mutations may allow selected patients to participate in trials of tyrosine kinase inhibitors.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.13209","type":"journal-article","created":{"date-parts":[[2015,11,7]],"date-time":"2015-11-07T02:24:10Z","timestamp":1446863050000},"page":"877-882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A case series of anal melanoma including the results of treatment with imatinib in selected patients"],"prefix":"10.1111","volume":"18","author":[{"given":"J.","family":"Knowles","sequence":"first","affiliation":[{"name":"Department of Colorectal Surgery Royal Free Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C.","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Cancer Surgery Peter MacCallum Cancer Centre Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. K.","family":"Warrier","sequence":"additional","affiliation":[{"name":"Department of Cancer Surgery Peter MacCallum Cancer Centre Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Henderson","sequence":"additional","affiliation":[{"name":"Department of Cancer Surgery Peter MacCallum Cancer Centre Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. G.","family":"Heriot","sequence":"additional","affiliation":[{"name":"Department of Cancer Surgery Peter MacCallum Cancer Centre Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,2]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"495","article-title":"Rare anal canal cancers in the U.S. veteran: patterns of disease and results of treatment","volume":"61","author":"Longo WE","year":"1995","journal-title":"Am Surg"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/02841860802120861"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19981015)83:8<1664::AID-CNCR23>3.0.CO;2-G"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1177\/000313480607201017","article-title":"Factors affecting survival in patients with anal melanoma","volume":"72","author":"Podnos YD","year":"2006","journal-title":"Am Surg"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0748-7983(96)92346-X"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02052442"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22681"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604791"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000265558"},{"key":"e_1_2_6_12_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2013"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6784"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2008.05.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2005.01.022"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.1822"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2493080240"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181b71228"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.03.002"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2009.116"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncponc1251"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13209","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T02:56:53Z","timestamp":1696301813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/codi.13209"],"URL":"https:\/\/doi.org\/10.1111\/codi.13209","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725947928.793550965","asserted-by":"object"}]},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"2015-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}