{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:20:17Z","timestamp":1789449617262,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T00:00:00Z","timestamp":1462233600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI12C0336"],"award-info":[{"award-number":["HI12C0336"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Many perianal fistulae in Crohn's disease do not respond to conventional surgical and medical management and recurrence rates are high. The study evaluated the safety and feasibility of allogeneic adipose\u2010derived stem cells for the treatment of perianal fistula in Crohn's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A multicentre, open\u2010label, dose escalation pilot study was performed. The first three patients (group 1) were administered 1\u00a0\u00d7\u00a010<jats:sup>7<\/jats:sup> cells\/ml based on the size of the fistula tract. Four\u00a0weeks later, after which time this dose had been confirmed to be safe, the next three patients (group 2) were administered 3\u00a0\u00d7\u00a010<jats:sup>7<\/jats:sup> cells\/ml. The end\u2010point was complete closure at 8\u00a0weeks after the injection. Patients who attended for the 8\u00a0week assessment were followed for an additional 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no adverse events of Grade 3 or 4 severity and no adverse events related to the treatment with allogeneic adipose\u2010derived stem cells. Two patients in group 1 achieved complete closure of the fistula at month 4 and month 6, and one patient in group 2 achieved complete closure at 8\u00a0weeks. The closure was sustained up to month 8 in all three of those patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These data suggest that allogeneic adipose\u2010derived stem cells may be a feasible treatment option for perianal fistula in Crohn's disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13223","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T11:58:50Z","timestamp":1448452730000},"page":"468-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Allogeneic adipose\u2010derived stem cells for the treatment of perianal fistula in Crohn's disease: a pilot clinical trial"],"prefix":"10.1111","volume":"18","author":[{"given":"K. J.","family":"Park","sequence":"first","affiliation":[{"name":"Department of Surgery Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.\u2010B.","family":"Ryoo","sequence":"additional","affiliation":[{"name":"Department of Surgery Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Seoul National University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. I.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. H.","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Surgery Yonsei University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Kyung Hee University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. Y.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Surgery Kyung Hee University College of Medicine Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Anterogen Co. Ltd Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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