{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:15:19Z","timestamp":1788200119314,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T00:00:00Z","timestamp":1472774400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"RIZIV\/INAMI"},{"name":"Belgian Ministry of Social Affairs"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>A fair to moderate concordance in grading of the total mesorectal excision (<jats:styled-content style=\"fixed-case\">TME<\/jats:styled-content>) surgical specimen by local pathologists and a central review panel has been observed in the <jats:styled-content style=\"fixed-case\">PROCARE<\/jats:styled-content> (Project on Cancer of the Rectum) project. The aim of the present study was to evaluate the difference, if any, in the accuracy of predicting the oncological outcome through <jats:styled-content style=\"fixed-case\">TME<\/jats:styled-content> grading by local pathologists or by the review panel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The quality of the <jats:styled-content style=\"fixed-case\">TME<\/jats:styled-content> specimen was reviewed for 482 surgical specimens registered on a prospective database between 2006 and 2011. Patients with a Stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content> tumour, with unknown incidence date or without follow\u2010up information were excluded, resulting in a study population of 383 patients. Quality assessment of the specimen was based on three grades including mesorectal resection (<jats:styled-content style=\"fixed-case\">MRR<\/jats:styled-content>), intramesorectal resection (<jats:styled-content style=\"fixed-case\">IMR<\/jats:styled-content>) and muscularis propria resection (<jats:styled-content style=\"fixed-case\">MPR<\/jats:styled-content>). Using univariable Cox regression models, local and review panel histopathological gradings of the quality of <jats:styled-content style=\"fixed-case\">TME<\/jats:styled-content> were assessed as predictors of local recurrence, distant metastasis and disease\u2010free and overall survival. Differences in the predictions between local and review grading were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Resection planes were concordant in 215 (56.1%) specimens. Downgrading from <jats:styled-content style=\"fixed-case\">MRR<\/jats:styled-content> to <jats:styled-content style=\"fixed-case\">MPR<\/jats:styled-content> was noted in 23 (6.0%). There were no significant differences in the prediction error between the two models; local and central review <jats:styled-content style=\"fixed-case\">TME<\/jats:styled-content> grading predicted the outcome equally well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Any difference in grading of the <jats:styled-content style=\"fixed-case\">TME<\/jats:styled-content> specimen between local histopathologists and the review panel had no significant impact on the prediction of oncological outcome for this patient cohort. Grading of the quality of <jats:styled-content style=\"fixed-case\">TME<\/jats:styled-content> as reported by local histopathologists can therefore be used for outcome analysis. Quality control of <jats:styled-content style=\"fixed-case\">TME<\/jats:styled-content> grading is not warranted provided the histopathologist is adequately trained.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13254","type":"journal-article","created":{"date-parts":[[2016,1,6]],"date-time":"2016-01-06T08:08:48Z","timestamp":1452067728000},"page":"883-888","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Review of the quality of total mesorectal excision does not improve the prediction of outcome"],"prefix":"10.1111","volume":"18","author":[{"given":"P.","family":"Demetter","sequence":"first","affiliation":[{"name":"Department of Pathology Erasme University Hospital ULB Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Jouret\u2010Mourin","sequence":"additional","affiliation":[{"name":"Department of Pathology Cliniques Universitaires Saint\u2010Luc UCL Brussels 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