{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:23:12Z","timestamp":1787314992110,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T00:00:00Z","timestamp":1459555200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\n                      This study aimed to review, consolidate and analyse the findings of studies investigating the efficacy of anal fistula plugs (\n                      <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content>\n                      s) in treating fistula\u2010in\u2010ano in patients with Crohn's disease.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A literature review was conducted via Pubmed, Embase, Medline, Scopus and the Cochrane Library for the period 1995\u20132015. Articles were selected and reviewed based on specific inclusion and exclusion criteria.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 16 studies were extracted, of which 12 were included in the systematic review. In total, 84 patients (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      1\u201320 per study) with a median age of 45 (18\u201372) years and a median follow\u2010up time of 9 (3\u201324) months were analysed. The total success rate, defined as closure of the fistula tract, was 49\/84 (58.3%, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      47\u201369). Success in patients with recurrent anal fistulae was 2\/5 (40%, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      5\u201385). Overall, the success rates of Surgisis\u00ae and\n                      <jats:styled-content style=\"fixed-case\">GORE<\/jats:styled-content>\n                      \u00ae\n                      <jats:styled-content style=\"fixed-case\">BIO<\/jats:styled-content>\n                      \u2010A\u00ae brand plugs were 48\/80 (60%, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      48\u201371) and 1\/4 (25%, 95%\n                      <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\n                      1\u201381). The recurrence rate of fistula\u2010in\u2010ano in the five studies that reported recurrence was 3\/22 (13.6%). In two comparative studies, inferior overall success rates were found in patients who received preoperative immunomodulators\n                      <jats:italic>vs<\/jats:italic>\n                      those who did not [3\/11 (27.3%)\n                      <jats:italic>vs<\/jats:italic>\n                      17\/23 (73.9%)].\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The studies suggest that the use of an\n                      <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content>\n                      in patients with Crohn's disease is a safe procedure with reasonable success, little morbidity and a low risk of incontinence. The current literature is limited by a number of factors, including small study cohorts, grouping of fistulae in Crohn's disease with other types of anal fistula, short and highly variable follow\u2010up times and multiple confounding factors such as number of fistula tracts, use of preoperative steroids or immunosuppressants, previous use of setons and variation in surgical technique.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/codi.13268","type":"journal-article","created":{"date-parts":[[2016,1,10]],"date-time":"2016-01-10T06:18:42Z","timestamp":1452406722000},"page":"351-356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["The anal fistula plug in Crohn's disease patients with fistula\u2010in\u2010ano: a systematic review"],"prefix":"10.1111","volume":"18","author":[{"given":"Y.","family":"Nasseri","sequence":"first","affiliation":[{"name":"The Surgery Group of Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cassella","sequence":"additional","affiliation":[{"name":"The Surgery Group of Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Berns","sequence":"additional","affiliation":[{"name":"The Surgery Group of Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Zaghiyan","sequence":"additional","affiliation":[{"name":"Division of Colon and Rectal Surgery Cedars\u2010Sinai Medical Center Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"The Surgery Group of Los Angeles Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.4263"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12906"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02070710"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800810947"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-6708-9"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000018804"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-004-0898-z"},{"key":"e_1_2_5_9_1","first-page":"1116","article-title":"Treatment of chronic fistula\u2010in\u2010ano using commercial fibrin glue","volume":"24","author":"Tinay OE","year":"2003","journal-title":"Saudi Med J"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00054725-200203000-00007"},{"key":"e_1_2_5_11_1","first-page":"1","article-title":"A prospective evaluation of the ligation of the intersphincteric tract procedure for complex anal fistula in patients with Crohn's disease","volume":"00","author":"Gingold DS","year":"2013","journal-title":"Ann Surg"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0755-3"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1084952102000940"},{"key":"e_1_2_5_14_1","first-page":"Doc13","article-title":"Gore BioA fistula plug in the treatment of high anal fistulas \u2013 initial results from a German multicenter\u2010study","volume":"10","author":"Ommer A","year":"2012","journal-title":"Ger Med Sci"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-0298-2"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-006-0695-y"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181d43b7d"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-007-9191-2"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-012-0897-3"},{"key":"e_1_2_5_20_1","first-page":"1584","article-title":"Anal fistula plug in high fistula\u2010in\u2010ano: an early Saudi experience","volume":"52","author":"Zubaidi A","year":"2009","journal-title":"Dis Colon Rectum"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gcb.2009.06.021"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.2010.05278.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e318239d1e4"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/DCR.0b013e31822d7ddd"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-014-1183-3"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-007-0398-4"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1553350609338041"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2010.01.007"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-012-0810-0"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13268","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13268","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T23:51:55Z","timestamp":1694649115000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1111\/codi.13268"],"URL":"https:\/\/doi.org\/10.1111\/codi.13268","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"2015-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-10-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}