{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T20:12:34Z","timestamp":1770322354315,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T00:00:00Z","timestamp":1472774400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Transanal endoscopic microsurgery (<jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content>) was originally invented by Buess <jats:italic>et\u00a0al<\/jats:italic>. (<jats:italic>Chirurg,<\/jats:italic> 1984, <jats:bold>55,<\/jats:bold> 677\u201380) for the treatment of infraperitoneal rectal adenomas. Its indications have progressively expanded to include larger and more advanced lesions. The aim of the study was to report the results of <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content> used for the treatment of circumferential rectal lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We retrospectively reviewed the medical records of 17 consecutive patients [median age 69 (32\u201389)\u00a0years; nine men] who underwent <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content> for a circumferential rectal lesion in our department between September 2010 and January 2015.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median distance from the anal verge was 4 (3\u201311)\u00a0cm, the median longitudinal extent was 7 (3\u201310)\u00a0cm and the median surface area was 75 (40\u2013255)\u00a0cm<jats:sup>2<\/jats:sup>. An end\u2010to\u2010end anastomosis without proximal bowel mobilization was completed endoscopically in all cases. The median operating time was 120 (40\u2013240)\u00a0min. Persistent, endoscopically uncontrollable endoluminal bleeding in one patient was successfully treated with a second <jats:styled-content style=\"fixed-case\">TEM<\/jats:styled-content> procedure. One patient underwent preoperative radiotherapy for adenocarcinoma detected at the preoperative assessment. Surgical histology showed a <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>3 cancer in one patient who refused further surgery, a <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>2 cancer in two who subsequently underwent abdominoperineal resection, a <jats:styled-content style=\"fixed-case\">pT<\/jats:styled-content>1 cancer in four and a ypT0 in one patient. All are at present free of disease. No patients developed faecal incontinence or urinary or sexual dysfunction. Four patients required endoscopic balloon dilatation for stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transanal endoscopic microsurgery is a feasible and safe technique for large circumferential lesions with a satisfactory outcome. Preoperative staging may be inaccurate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13279","type":"journal-article","created":{"date-parts":[[2016,1,20]],"date-time":"2016-01-20T02:01:08Z","timestamp":1453255268000},"page":"897-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Transanal endoscopic microsurgery for giant circumferential rectal adenomas"],"prefix":"10.1111","volume":"18","author":[{"given":"A.","family":"Arezzo","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences University of Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Arolfo","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. E.","family":"Allaix","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bullano","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Miegge","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Marola","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Morino","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences University of Torino Torino Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,2]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"677","article-title":"A system for a transanal endoscopic rectum operation","volume":"55","author":"Buess G","year":"1984","journal-title":"Chirurg"},{"key":"e_1_2_8_3_1","first-page":"133","article-title":"Local therapy of rectum carcinoma. a prospective follow\u2010up study","volume":"67","author":"Mentges B","year":"1996","journal-title":"Chirurg"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-012-0936-0"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e3181b14d2d"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-013-0984-0"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-005-0025-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-3238-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-014-1920-0"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1256111"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-007-0358-z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-012-2418-x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-011-1132-9"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13279","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:57:01Z","timestamp":1696316221000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/codi.13279"],"URL":"https:\/\/doi.org\/10.1111\/codi.13279","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"2015-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}