{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T15:40:51Z","timestamp":1789918851695,"version":"4.0.1"},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T00:00:00Z","timestamp":1462233600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Karl Storz"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pilonidal disease (<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>) is a common inflammatory disease of the gluteal fold, resulting in recurrent acute\/chronic infection at the level of the natal cleft. In this study, endoscopic pilonidal sinus\u00a0treatment (<jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>iT), a new endoscopic minimally invasive procedure, was evaluated for its effectiveness in treating\u00a0<jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two hundred and fifty prospective patients with chronic <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> were enrolled in a prospective multicentre study conducted at a secondary and tertiary colorectal surgery centre. The primary end\u2010point of this study was wound healing, and the short\u2010\/long\u2010term outcomes such as healing time, morbidity rate and recurrence rate were analysed. The secondary end\u2010point of this study was quality of life (QoL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The complete wound healing rate was 94.8%, and the mean complete wound healing time was 26.7\u00a0\u00b1\u00a010.4\u00a0days. The incomplete healing rate (5.2%) was significantly related to the number of external openings (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01). There was no difference in the failure rate when <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>iT was performed as the first\u2010line treatment for <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content> or when it was used after unsuccessful procedures (<jats:italic>P\u00a0<\/jats:italic>=\u00a0n.s.). Recurrence occurred in 12 cases (5%). The QoL significantly increased from preoperative levels 15\u00a0days after the <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>iT procedure (45.3 <jats:italic>vs<\/jats:italic> 7.9; <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>iT procedure is a safe and effective technique for treating <jats:styled-content style=\"fixed-case\">PD<\/jats:styled-content>. It provides better short\u2010 and long\u2010term outcomes than various other techniques that are more invasive. <jats:styled-content style=\"fixed-case\">EPS<\/jats:styled-content>iT is a minimally invasive outpatient procedure, which is associated with a quick recovery and a good QoL outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13322","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T11:34:40Z","timestamp":1457264080000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":108,"title":["Endoscopic pilonidal sinus treatment: a prospective multicentre trial"],"prefix":"10.1111","volume":"18","author":[{"given":"P.","family":"Meinero","sequence":"first","affiliation":[{"name":"Colorectal Unit Sanatrix Clinic Rome and Sestri Levante Hospital Genova Italy"},{"name":"Department of Surgery EOC Hospital Mendrisio Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Stazi","sequence":"additional","affiliation":[{"name":"Pelvic Care Center Madonna delle Grazie Hospital Velletri Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Carbone","sequence":"additional","affiliation":[{"name":"Colorectal Unit Sanatrix Clinic Rome and Sestri Levante Hospital Genova Italy"},{"name":"Sapienza University of Rome Policlinico Umberto I Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fasolini","sequence":"additional","affiliation":[{"name":"Department of Surgery EOC Hospital Mendrisio Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Regusci","sequence":"additional","affiliation":[{"name":"Department of Surgery EOC Hospital Mendrisio Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7051-6120","authenticated-orcid":false,"given":"M.","family":"La Torre","sequence":"additional","affiliation":[{"name":"Colorectal Unit Sanatrix Clinic Rome and Sestri Levante Hospital Genova Italy"},{"name":"Sapienza University of Rome Policlinico Umberto I Hospital Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,3]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"CD006213","article-title":"Healing by primary versus secondary intention after surgical treatment for pilonidal sinus","author":"McCallum I","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335373"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800560107"},{"key":"e_1_2_9_5_1","first-page":"567","article-title":"Pilonidal disease: origin 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