{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T09:32:03Z","timestamp":1766136723719,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T00:00:00Z","timestamp":1480636800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The study evaluated the outcome of severe acute antipsychotic (neuroleptic) drug related colitis requiring emergency surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>From 2009 to 2014, 20 patients underwent emergency surgery for acute and severe neuroleptic\u2010related ischaemic colitis. Neuroleptic\u2010induced colitis was defined as another cause besides inflammatory, infectious or ischaemic colitis with a relationship to treatment by antipsychotic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The main drugs involved were cyamemazine (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>9, 45%), loxapine (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>5, 25%), haloperidol (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4, 20%) and alimemazine (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>4, 20%). Most (<jats:italic>n\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>14, 70%) patients presented with haemodynamic instability requiring massive resuscitation and vasopressive drugs. <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> signs of digestive impairment were found in 13 (65%) patients having emergency surgery. The lesions were pancolonic in 40%; transparietal necrosis was found in 45% and 15% had colonic perforation. Twelve (60%) patients had total or subtotal colectomy and eight (40%) a segmental colectomy with colostomy or ileostomy in all cases. The postoperative mortality was 15% and morbidity was 70%, necessitating surgical reintervention in two (10%) patients. Of the 17 surviving patients, 11 (64.7%) had restoration of intestinal continuity after a median delay of 103\u00a0days, with a postoperative morbidity rate of 36.3%. In the intent\u2010to\u2010treat population, the permanent stoma rate was 30%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The morbidity and mortality of surgery for neuroleptic\u2010drug\u2010induced colitis is higher than for colitis due to other causes. A better knowledge of this condition should lead to early diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13376","type":"journal-article","created":{"date-parts":[[2016,5,11]],"date-time":"2016-05-11T15:13:23Z","timestamp":1462979603000},"page":"1179-1185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Outcome of emergency surgery for severe neuroleptic\u2010induced colitis: results of a prospective cohort"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7666-9497","authenticated-orcid":false,"given":"S.","family":"Abdalla","sequence":"first","affiliation":[{"name":"Department of Digestive and Oncologic Surgery Bic\u00eatre Hospital Assistance Publique \u2013 H\u00f4pitaux de Paris University Paris\u2010Sud Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Brouquet","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncologic Surgery Bic\u00eatre Hospital Assistance Publique \u2013 H\u00f4pitaux de Paris University Paris\u2010Sud Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Lazure","sequence":"additional","affiliation":[{"name":"Department of Pathology Bic\u00eatre Hospital Assistance Publique \u2013 H\u00f4pitaux de Paris University Paris\u2010Sud Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Costaglioli","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncologic Surgery Bic\u00eatre Hospital Assistance Publique \u2013 H\u00f4pitaux de Paris University Paris\u2010Sud Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Penna","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncologic Surgery Bic\u00eatre Hospital Assistance Publique \u2013 H\u00f4pitaux de Paris University Paris\u2010Sud Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Benoist","sequence":"additional","affiliation":[{"name":"Department of Digestive and Oncologic Surgery Bic\u00eatre Hospital Assistance Publique \u2013 H\u00f4pitaux de Paris University Paris\u2010Sud Le Kremlin\u2010Bic\u00eatre France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,2]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"778","article-title":"Causal assessment of drug\u2010induced acute colitis. 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