{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:10:38Z","timestamp":1784581838085,"version":"3.55.0"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National High Technology Research and Development Program of China (863 Program)"},{"name":"Ministry of Science and Technology of China","award":["2012AA021103"],"award-info":[{"award-number":["2012AA021103"]}]},{"name":"Research Fund of Public Welfare in the Health Industry","award":["201502039"],"award-info":[{"award-number":["201502039"]}]},{"name":"National Health and Family Planning Commission of China"},{"name":"Key Clinical Specialty Discipline Construction Program"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Previous randomized controlled trials and meta\u2010analyses have demonstrated the ineffectiveness of fluorouracil\u2010based adjuvant chemotherapy for patients with rectal cancer who have undergone neoadjuvant chemoradiotherapy and subsequent surgery. The role of oxaliplatin\/fluorouracil\u2010based adjuvant chemotherapy in such patients is unknown. We performed a meta\u2010analysis to evaluate the efficacy of oxaliplatin\/fluorouracil\u2010based adjuvant chemotherapy based on a comparison with fluorouracil\u2010based adjuvant chemotherapy for patients with rectal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A literature search of <jats:styled-content style=\"fixed-case\">MEDLINE<\/jats:styled-content>, Embase, Web of Science, Cochrane Library and ClinicalTrials.gov was performed to identify eligible studies. The primary end\u2010point of interest was disease\u2010free survival (<jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content>). The secondary end\u2010points were overall survival, compliance and the incidence of Grade 3 or 4 toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The literature search identified four randomized controlled trials that met the inclusion criteria for the meta\u2010analysis, and 2793 patients with pathological <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> or clinical <jats:styled-content style=\"fixed-case\">TNM<\/jats:styled-content> Stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> disease were included. The meta\u2010analysis showed that oxaliplatin\/fluorouracil\u2010based adjuvant chemotherapy was associated with a significantly improved <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content> (hazard ratio 0.85; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.73\u22120.98; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.03), comparable compliance (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.18; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0.95\u22121.46; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.13) and a higher incidence of vomiting or nausea (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.47; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.21\u22125.05; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01). No significant differences were observed between the groups with respect to overall survival and the incidence of leucopaenia, anaemia, thrombocytopaenia and diarrhoea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Adjuvant oxaliplatin\/fluorouracil\u2010based chemotherapy can improve the <jats:styled-content style=\"fixed-case\">DFS<\/jats:styled-content> of patients after neoadjuvant chemoradiotherapy and radical surgery, compared with adjuvant fluorouracil\u2010based chemotherapy. Data of the longer\u2010term survival outcome are needed.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13381","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T07:50:11Z","timestamp":1463039411000},"page":"763-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Oxaliplatin\/fluorouracil\u2010based adjuvant chemotherapy for locally advanced rectal cancer after neoadjuvant chemoradiotherapy and surgery: a systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1111","volume":"18","author":[{"given":"L.","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of General Surgery Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Nanfang Hospital Southern Medical 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery Nanfang Hospital Southern Medical University Guangzhou 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