{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T17:08:53Z","timestamp":1784740133712,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,1,5]],"date-time":"2017-01-05T00:00:00Z","timestamp":1483574400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Chronic constipation can be aetiopathogenically classified into slow transit constipation (<jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content>), rectal evacuation difficulty (<jats:styled-content style=\"fixed-case\">RED<\/jats:styled-content>) or a combination (<jats:styled-content style=\"fixed-case\">BOTH<\/jats:styled-content>). Although the efficacy of percutaneous tibial nerve stimulation (<jats:styled-content style=\"fixed-case\">PTNS<\/jats:styled-content>) in faecal incontinence has been well proved, a current literature search identifies only one study which assessed its effect on constipation. We aimed to evaluate the effectiveness of <jats:styled-content style=\"fixed-case\">PTNS<\/jats:styled-content> in patients with different causes of constipation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Thirty\u2010four patients [30 women, median age 50 (20\u221279) years] with constipation who had previously failed maximal laxative and biofeedback therapy participated in the study. All patients underwent a baseline radio\u2010opaque marker transit study and anorectal physiology examination. All had 12 sessions of <jats:styled-content style=\"fixed-case\">PTNS<\/jats:styled-content> of 30\u00a0min per session. A fall in the Wexner constipation score to \u226415 or by \u22655 points was taken as the primary outcome. Secondary outcomes included the results of pre\u2010 and post\u2010 <jats:styled-content style=\"fixed-case\">PTNS<\/jats:styled-content> transit and anorectal physiology studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eleven patients had <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content>, 14 had <jats:styled-content style=\"fixed-case\">RED<\/jats:styled-content> and nine had <jats:styled-content style=\"fixed-case\">BOTH<\/jats:styled-content>. A response was seen in four patients (1\/11 <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content>, 2\/14 <jats:styled-content style=\"fixed-case\">RED<\/jats:styled-content> and 1\/9 <jats:styled-content style=\"fixed-case\">BOTH<\/jats:styled-content>). Comparing pre\u2010 and post\u2010 <jats:styled-content style=\"fixed-case\">PTNS<\/jats:styled-content>, there was no significant change in the mean Wexner score (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.10). There was no change in colonic transit time among the whole population (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.56) or among those with <jats:styled-content style=\"fixed-case\">STC<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.47). There was no improvement in balloon expulsion in the whole group (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.73) or in patients with <jats:styled-content style=\"fixed-case\">RED<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.69).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PTNS<\/jats:styled-content> is of no benefit to patients with constipation, whatever aetiopathogenic mechanism is responsible for the symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13388","type":"journal-article","created":{"date-parts":[[2016,5,21]],"date-time":"2016-05-21T15:02:07Z","timestamp":1463842927000},"page":"45-49","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effectiveness of percutaneous tibial nerve stimulation in managing refractory constipation"],"prefix":"10.1111","volume":"19","author":[{"given":"L.","family":"Kumar","sequence":"first","affiliation":[{"name":"GI Physiology Unit University College Hospital London UK"},{"name":"Division of Medicine University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Liwanag","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Athanasakos","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Raeburn","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Zarate\u2010Lopez","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. V.","family":"Emmanuel","sequence":"additional","affiliation":[{"name":"GI Physiology Unit University College Hospital London UK"},{"name":"Division of Medicine University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04273.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12371"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10151-013-0985-z"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nau.22296"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)75152-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2011.02820.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.028"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2490-13-61"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12428"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/560802"},{"key":"e_1_2_8_12_1","first-page":"192","article-title":"Good results with transcutaneous tibial nerve stimulation for advanced chronic constipation treatment","volume":"13","author":"Ieva Stundien\u2250 P\u017d","year":"2014","journal-title":"Lithuanian Surgery"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1998.274.1.G186"},{"key":"e_1_2_8_14_1","first-page":"344","article-title":"Combined (thalamotomy and stimulation) stereotactic surgery of the VIM thalamic nucleus for bilateral Parkinson disease","volume":"50","author":"Benabid AL","year":"1987","journal-title":"Appl Neurophysiol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200009)15:5<919::AID-MDS1024>3.0.CO;2-0"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.10.029"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13388","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13388","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13388","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T07:47:15Z","timestamp":1696319235000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1111\/codi.13388"],"URL":"https:\/\/doi.org\/10.1111\/codi.13388","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"2015-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-01-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}