{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T09:21:10Z","timestamp":1696411270209},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T00:00:00Z","timestamp":1472774400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>) develops from normal epithelium, through dysplastic adenoma to invasive carcinoma. In addition to familial adenomatous polyposis and Lynch syndrome, approximately 10\u201335% of <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>s are familial in nature. <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> screening and surveillance programmes are based on an understanding of the natural history of polyps and rely on the ability to remove premalignant lesions endoscopically before they are capable of developing invasion. There are, however, significant differences in these guidelines between the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> and the <jats:styled-content style=\"fixed-case\">USA<\/jats:styled-content> in relation to the weight attributed to a family history of polyps. Here, using publicly available national data sets, we show that these differences in guidelines unexpectedly generate inadequate screening recommendations for second\u2010degree relatives of patients with <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>. We validate our simple mathematical modelling of the clinical problem on a regional data set as well as previously published study data to demonstrate the correct interpretation. We further discuss the implications of a family history of adenoma formation in the current climate of the Bowel Cancer Screening Programme and suggest a re\u2010evaluation of the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> guidelines in the light of this developing issue.<\/jats:p>","DOI":"10.1111\/codi.13391","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T14:59:27Z","timestamp":1464015567000},"page":"842-845","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adenomas as a risk factor in familial colorectal cancer: implications for screening and surveillance in the <scp>UK<\/scp>"],"prefix":"10.1111","volume":"18","author":[{"given":"S. J. A.","family":"Buczacki","sequence":"first","affiliation":[{"name":"Li Ka Shing Centre Cancer Research UK Cambridge Institute Cambridge UK"},{"name":"Cambridge Colorectal Unit Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M. D.","family":"Wheeler","sequence":"additional","affiliation":[{"name":"Cambridge Colorectal Unit Addenbrooke's Hospital Cambridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,2]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2005.09.023"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2000.16508"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007133430201"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198809013190901"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2009.179804"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.02.002"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12405"},{"key":"e_1_2_2_9_1","unstructured":"Cancer Research UK.2015.http:\/\/www.cancerresearchuk.org\/health-professional\/cancer-statistics\/statistics-by-cancer-type\/bowel-cancer(accessed March 2015)."},{"key":"e_1_2_2_10_1","unstructured":"Surveillance Epidemiology and End Results Database.http:\/\/www.seer.cancer.gov\/popdata(accessed January 2015) National Cancer Institute DCCPS Surveillance Research Program Surveillance Systems Branch."},{"key":"e_1_2_2_11_1","unstructured":"Office for National Statistics.2012.http:\/\/www.ons.gov.uk(accessed March 2015)."},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.04677.x"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28227"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.07.023"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2012.01.046"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/cgh.2003.50018"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70358-0"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2010.07.005"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h6080"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2009.05.032"},{"key":"e_1_2_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.10.001"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.12.010"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13391","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13391","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:53:45Z","timestamp":1696316025000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1111\/codi.13391"],"URL":"https:\/\/doi.org\/10.1111\/codi.13391","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"2016-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}