{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:59:35Z","timestamp":1784303975126,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,3]],"date-time":"2017-02-03T00:00:00Z","timestamp":1486080000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007398","name":"Strategiske Forskningsr\u00e5d","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007398","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Our unit has recently shown that sacral nerve stimulation (<jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content>) has a significantly positive short\u2010term effect on selected patients with diarrhoea\u2010predominant or mixed irritable bowel syndrome (<jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>). The aim of the present prospective study was to evaluate the medium\u2010term efficacy of <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> for IBS to establish whether SNS could have a future role in the treatment of <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Patients with <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content> who had previously been implanted with a permanent neurostimulator as part of a randomized, controlled, crossover study, were assessed for medium\u2010term follow\u2010up. The primary end\u2010point was change in the IBS\u2010specific symptom score (Gastrointestinal Symptom Rating Scale\u2013Irritable Bowel Syndrome version questionnaire) from baseline to 3\u2010year follow\u2010up. The secondary end\u2010point was a change in the <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010specific quality of life score (Irritable Bowel Syndrome\u2013Impact Scale questionnaire) from baseline to 3\u2010year follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 26 patients, 20 were eligible for 3\u2010year follow\u2010up. The median <jats:styled-content style=\"fixed-case\">IBS<\/jats:styled-content>\u2010specific symptom score was significantly lower at 3\u2010year follow\u2010up (30, range 13\u201371) than at baseline (62, 45\u201380) (<jats:italic>P\u00a0<\/jats:italic>=\u00a00.0001). The effect was observed in all symptom clusters within the score. Also, the median IBS\u2010specific quality of life score was significantly improved at 3\u2010year follow\u2010up (52, 26\u2013169) compared with baseline (135, 82\u2013180, <jats:italic>P\u00a0<\/jats:italic>=\u00a00.0002). The effect was observed in all domains of the score. As per the protocol, 75% of patients were judged therapeutic successes. Seventy per cent of patients had a more than 50% reduction in daily IBS symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>At medium\u2010term follow\u2010up, <jats:styled-content style=\"fixed-case\">SNS<\/jats:styled-content> continues to be an effective treatment for highly selected patients with diarrhoea\u2010predominant or mixed IBS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13428","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T19:58:37Z","timestamp":1466625517000},"page":"188-193","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Three\u2010year follow\u2010up of sacral nerve stimulation for patients with diarrhoea\u2010predominant and mixed irritable bowel syndrome"],"prefix":"10.1111","volume":"19","author":[{"given":"J.","family":"Fassov","sequence":"first","affiliation":[{"name":"Surgical Research Unit Department of Surgery P Aarhus University Hospital Aarhus Denmark"},{"name":"Neurogastroenterology Unit Department of Hepatology and Gastroenterology V Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lundby","sequence":"additional","affiliation":[{"name":"Surgical Research Unit Department of Surgery P Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Laurberg","sequence":"additional","affiliation":[{"name":"Surgical Research Unit Department of Surgery P Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Buntzen","sequence":"additional","affiliation":[{"name":"Surgical Research Unit Department of Surgery P Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Krogh","sequence":"additional","affiliation":[{"name":"Neurogastroenterology Unit Department of Hepatology and Gastroenterology V Aarhus University Hospital Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2012.02.029"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldh039"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.32978"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/codi.12905"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.6083"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.5111"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e3182196ff4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/DCR.0b013e31820348ac"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2006.01096.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10350-008-9255-y"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0000000000000559"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310004209"},{"key":"e_1_2_8_15_1","unstructured":"Clinical investigation of medical devices for human subjects \u2013 Good clinical practice. 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