{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:41:50Z","timestamp":1790228510283,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T00:00:00Z","timestamp":1470096000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Ulcerative colitis (<jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content>) is considered to be a disease of continuous mucosal inflammation extending proximally from the rectum. However, appendiceal orifice inflammation (<jats:styled-content style=\"fixed-case\">AOI<\/jats:styled-content>) is a skip lesion with segments of continuous involvement from the rectum. The aim of this study was to examine the clinical characteristics and clinical course, particularly focused on proximal extension, of <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">AOI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective evaluation of patients with <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> who underwent total colonoscopy at the Department of Surgical Oncology, The University of Tokyo, from 2004 to 2014. The degree of <jats:styled-content style=\"fixed-case\">AOI<\/jats:styled-content> was graded endoscopically as follows: 0 (no inflammation); 1 (slight oedema); 2 (moderate inflammation); and 3 (marked inflammation). A total of 189 patient records were reviewed retrospectively. The presence of <jats:styled-content style=\"fixed-case\">AOI<\/jats:styled-content> was analysed with regard to the clinical information of each patient, and its association with proximal extension of proctitis or left\u2010sided colitis was evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 189 patients with <jats:styled-content style=\"fixed-case\">UC<\/jats:styled-content> who underwent total colonoscopy at our institution, 92 were diagnosed with pancolitis, 50 with left\u2010sided colitis and 47 with proctitis. Endoscopic findings of <jats:styled-content style=\"fixed-case\">AOI<\/jats:styled-content> were observed in 26 patients, including 11 (12.0%) with pancolitis, six (12.0%) with left\u2010sided colitis and nine (19.1%) with proctitis. During follow up, proximal extension of the disease occurred in all nine patients with proctitis <jats:styled-content style=\"fixed-case\">AOI<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">AOI<\/jats:styled-content> is more frequently observed in patients with proctitis. Our results showed correlations between <jats:styled-content style=\"fixed-case\">AOI<\/jats:styled-content> and subsequent proximal extension of mucosal inflammation in patients with proctitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13435","type":"journal-article","created":{"date-parts":[[2016,6,29]],"date-time":"2016-06-29T09:09:34Z","timestamp":1467191374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Appendiceal orifice inflammation is associated with proximal extension of disease in patients with ulcerative colitis"],"prefix":"10.1111","volume":"18","author":[{"given":"H.","family":"Anzai","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Kishikawa","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Otani","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Kiyomatsu","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nozawa","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Kazama","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Sunami","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology The University of Tokyo Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,8,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020831"},{"key":"e_1_2_7_3_1","first-page":"151","article-title":"\u201cUlcerative appendicitis\u201d occurring as a skip lesion in chronic ulcerative colitis; 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