{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:23:40Z","timestamp":1792787020240,"version":"4.5.0"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T00:00:00Z","timestamp":1488412800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Digestive Disorders Foundation, Suffolk"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2017,3]]},"abstract":"Abstract<\/jats:title>\n \n Aim<\/jats:title>\n \n A large, prospectively collected, clinical database was analysed to determine the various pre\u2010 and intra\u2010operative factors affecting anastomotic leakage (\n AL<\/jats:styled-content>\n ) in colorectal surgery.\n <\/jats:p>\n <\/jats:sec>\n \n Method<\/jats:title>\n \n Data on 17\u00a0518 patients having a colorectal resection with anastomosis, taken from the 2013 American College of Surgeons National Surgical Quality Improvement Program database, were included in the study. Multivariable logistic regression analysis was carried out to identify risk\u2010adjusted predictive factors for\n AL<\/jats:styled-content>\n . Statistical significance was set at\n P<\/jats:italic>\n \u00a0<\u00a00.05 and confidence intervals were reported at the 95% level.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The\n AL<\/jats:styled-content>\n rate was 3.9% (687\/17\u00a0518). Younger patients, male gender and an American Society of Anesthesiology (\n ASA<\/jats:styled-content>\n ) score of \u2265\u00a03 (\n P<\/jats:italic>\n \u00a0<\u00a00.001), smoking (\n P<\/jats:italic>\n \u00a0=\u00a00.001), diabetes (\n P<\/jats:italic>\n \u00a0=\u00a00.035), a preoperative serum albumin level of <\u00a04\u00a0g\/dl (\n P<\/jats:italic>\n \u00a0=\u00a00.030), elective rectal cancer surgery (\n P<\/jats:italic>\n \u00a0=\u00a00.024), emergency colectomy for bleeding (\n P<\/jats:italic>\n \u00a0=\u00a00.013) and splenic flexure mobilization (\n P<\/jats:italic>\n \u00a0=\u00a00.043) were associated with an increased risk of\n AL<\/jats:styled-content>\n . Preoperative oral antibiotics (\n P<\/jats:italic>\n \u00a0<\u00a00.001), right hemicolectomy (open or laparoscopic) and laparoscopic partial colectomy were associated with a reduced risk of\n AL<\/jats:styled-content>\n compared with the entire group. Body mass index, preoperative chemotherapy, emergency surgery and mechanical bowel preparation were not related to\n AL<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n In contrast to most studies, younger age was found to be an independent risk factor for\n AL<\/jats:styled-content>\n . The risk for\n AL<\/jats:styled-content>\n was lower with laparoscopic partial colectomy and open or laparoscopic right hemicolectomy. Preoperative oral antibiotic preparation significantly reduces the risk of\n AL<\/jats:styled-content>\n and should be incorporated as a standard protocol.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/codi.13476","type":"journal-article","created":{"date-parts":[[2017,3,2]],"date-time":"2017-03-02T01:20:59Z","timestamp":1488417659000},"page":"288-298","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":162,"title":["Risk factors for anastomotic leakage after colorectal resection: a retrospective analysis of 17\u00a0518 patients"],"prefix":"10.1111","volume":"19","author":[{"given":"M.","family":"Parthasarathy","sequence":"first","affiliation":[{"name":"Ipswich Hospital NHS Trust Ipswich UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Greensmith","sequence":"additional","affiliation":[{"name":"Ipswich Hospital NHS Trust Ipswich 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