{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T07:43:18Z","timestamp":1696059798843},"reference-count":22,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Colorectal Disease"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Very few studies have compared the epidemiological characteristics of patients with familial colorectal cancer Type X (<jats:styled-content style=\"fixed-case\">FCCTX<\/jats:styled-content>) with those of sporadic colorectal cancer (S\u2010<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>). The aim of this study was to compare clinicopathological characteristics and survival between <jats:styled-content style=\"fixed-case\">FCCTX<\/jats:styled-content> and S\u2010<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> in patients from a historically isolated geographical region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective study was carried out of patients with S\u2010<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FCCTX<\/jats:styled-content> treated in the Canary Islands. Family and personal history of colorectal cancer (<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>) were recorded, together with genetic (microsatellite instability), immunohistochemical and clinical variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010eight (10.6%) of 451 patients were classified as <jats:styled-content style=\"fixed-case\">FCCTX<\/jats:styled-content> and the remaining 403 (89.4%) as S\u2010<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>. Age at the diagnosis of tumour was significantly lower in <jats:styled-content style=\"fixed-case\">FCCTX<\/jats:styled-content> than in S\u2010<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> (64.06\u00a0\u00b1\u00a012.65\u00a0years <jats:italic>vs<\/jats:italic> 69.13\u00a0\u00b1\u00a010.80 years; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.01; <jats:italic>Z\u00a0<\/jats:italic>=\u00a0\u22122.48). Patients with FCCTX had a larger number of synchronous tumours (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.09). Recurrence was significantly higher in <jats:styled-content style=\"fixed-case\">FCCTX<\/jats:styled-content> than in S\u2010<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> (18.7% <jats:italic>vs<\/jats:italic> 8.6%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). Survival correlated significantly with the number of first\u2010degree and second\u2010degree relatives with <jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.04; OR:\u00a01.368, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.01\u20131.84, and <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04; OR:\u00a01.363, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.08\u20131.65) and with the total number of cases of CRC in the immediate family (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01; <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>:\u00a01.377, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.17\u20131.61). Recurrence\u2010free time was significantly lower in patients with <jats:styled-content style=\"fixed-case\">FCCTX<\/jats:styled-content> (log\u2010rank\u00a0=\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Significant differences were found in several demographic and clinicopathological variables between patients with <jats:styled-content style=\"fixed-case\">FCCTX<\/jats:styled-content> and patients with S\u2010<jats:styled-content style=\"fixed-case\">CRC<\/jats:styled-content>. These included increased tumour presentation under the age of 50\u00a0years and a higher recurrence rate in patients with <jats:styled-content style=\"fixed-case\">FCCTX<\/jats:styled-content>, suggesting an increased risk of CRC in this group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/codi.13532","type":"journal-article","created":{"date-parts":[[2016,9,27]],"date-time":"2016-09-27T08:53:10Z","timestamp":1474966390000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Clinicopathological differences between familial colorectal cancer type X and sporadic cancer in an isolated area of spain"],"prefix":"10.1111","volume":"18","author":[{"given":"V.","family":"Medina\u2010Arana","sequence":"first","affiliation":[{"name":"Department of General and Digestive Surgery Hospital Universitario de Canarias La Laguna, Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rahy\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery Hospital Universitario de Canarias La Laguna, Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Delgado\u2010Plasencia","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery Hospital Universitario de Canarias La Laguna, Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mart\u00ednez\u2010Riera","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Universitario de Canarias La Laguna, Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Le\u00f3n\u2010Ayll\u00f3n","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery Hospital Universitario de Canarias La Laguna, Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Rodr\u00edguez\u2010Castellano","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery Hospital Universitario de Canarias La Laguna, Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bravo\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Department of General and Digestive Surgery Hospital Universitario de Canarias La Laguna, Tenerife Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Fern\u00e1ndez\u2010Peralta","sequence":"additional","affiliation":[{"name":"Department of Biology\u2010Genetics Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. J.","family":"Gonz\u00e1lez\u2010Aguilera","sequence":"additional","affiliation":[{"name":"Department of Biology\u2010Genetics Universidad Aut\u00f3noma de Madrid Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.16.1979"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i29.9828"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0965"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.060905"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.9781"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10689-011-9473-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1208387"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.01.035"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.26093"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.11.011"},{"key":"e_1_2_7_12_1","first-page":"5248","article-title":"A National Cancer Institute workshop on Microsatellite Instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer","volume":"58","author":"Boland CR","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2005.12.033"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22454"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071755"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.06.009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e31818fa2db"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.03.014"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyu190"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.309"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2009.07.003"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/11.20.2507"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e3181b0452f"}],"container-title":["Colorectal Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13532","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcodi.13532","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/codi.13532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T23:12:17Z","timestamp":1696029137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/codi.13532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/codi.13532"],"URL":"https:\/\/doi.org\/10.1111\/codi.13532","archive":["Portico"],"relation":{},"ISSN":["1462-8910","1463-1318"],"issn-type":[{"value":"1462-8910","type":"print"},{"value":"1463-1318","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11]]},"assertion":[{"value":"2016-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-07-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}